Asia Pac Allergy.  2015 Jul;5(3):156-162. 10.5415/apallergy.2015.5.3.156.

Immunoglobulin E to allergen components of house dust mite in Korean children with allergic disease

• Kim HS
• Kang SH
• Won S
• Lee EK
• Chun YH
• Yoon JS
• Kim HH
• Kim JT

• KMID: 2397045
• DOI: http://doi.org/10.5415/apallergy.2015.5.3.156

Abstract

BACKGROUND
House dust mites (HDMs) are important sources of indoor allergens. Seventeen components have been identified from Dermatophagoides pteronyssinus (Der p).
OBJECTIVE
Our aim was to define the prevalence of specific IgE to components of Der p in Korea and investigate the clinical features of them in children with allergic disease.
METHODS
We performed a prospective evaluation of 80 HDM sensitized patients with history of allergic rhinitis (AR), atopic dermatitis (AD), asthma and urticaria (UC). Patients underwent ImmunoCAP for total IgE, Der p, Der f, Der p 1, Der p 2, and Der p 10.
RESULTS
Seventy-nine patients had detectable serum IgE to Der p, 80 patients were sensitized to Der f, 66 patients were sensitized to Der p 1, 63 patients to Der p 2, and 7 patients were sensitized to Der p 10. Der p 1 specific IgE was significantly lower in the UC group compared with the AD and AR group. Total IgE was significantly higher in the Der p 10 sensitized group. Der p 10 serum IgE level was highly correlated with crab and shrimp specific IgE. There was a significant positive correlation between total IgE and specific IgE to Der p and its components and Der f.
CONCLUSION
Sensitization to HDM and its components in Korea is similar to previous studies from temperate climate. The determination of Der p 1, Der p 2, and Der p 10 specific IgE helps in obtaining additional information in regards to allergic disease.

Keyword

Immunoglobulin E; Dermatophagoides pteronyssinus antigen p 1; Dermatophagoides pteronyssinus antigen p 2; der p 10 protein, Dermatophagoides pteronyssinus; Hypersensitivity, Immediate; Child

MeSH Terms

Allergens
Asthma
Child*
Climate
Dermatitis, Atopic
Dermatophagoides pteronyssinus
Dust*
Humans
Hypersensitivity, Immediate
Immunoglobulin E*
Immunoglobulins*
Korea
Prevalence
Prospective Studies
Pyroglyphidae*
Rhinitis, Allergic
Urticaria
Allergens
Dust
Immunoglobulin E
Immunoglobulins

Figure

• 

  Fig. 1 Specific IgE response to Dermatophagoides pteronyssinus (Der p) allergenic components and Dermatophagoides farinae (Der f).

• 

  Fig. 2 Specific IgE titer for Dermatophagoides pteronyssinus (Der p) (A), Dermatophagoides farinae (Der f) (B), Der p 1 (C), Der p 2 (D), and Der p 10 (E) according to the allergic disease. AR. allergic rhinitis; AS, asthma; AD, atopic dermatitis; UC, urticaria.

• 

  Fig. 3 Correlation between Dermatophagoides pteronyssinus (Der p) 10 specific IgE and specific IgE to shrimp (A), crab (B), and cockroach (C).

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