Asia Pac Allergy.  2015 Oct;5(4):222-229. 10.5415/apallergy.2015.5.4.222.

Pilot study of the use of Yin Qiao San in children with conventional antipyretic hypersensitivity

Affiliations
  • 1Department of Paediatric Medicine, Allergy Service, KK Women's and Children's Hospital, Singapore 229899, Singapore. loh.wenyin@singhealth.com.sg
  • 2Allergy and Clinical Immunology Unit, Sheba Medical Center, Tel Hashomer 5262100, Israel.

Abstract

BACKGROUND
Children with a diagnosis of cross-reactive hypersensitivity to both paracetamol and nonsteroidal anti-inflammatory drugs are limited in their choice of antipyretics.
OBJECTIVE
The aim of this pilot study is to evaluate the feasibility of using a Chinese proprietary medicine, Yin Qiao San (YQS), for fever relief.
METHODS
A single centre, open label, prospective clinical trial exploring the tolerability and feasibility of using YQS for fever relief in children who are unable to use conventional antipyretic medications. Children between 1-18 years of age with hypersensitivity to multiple antipyretics were recruited. Eligible participants underwent an oral provocation test with YQS. Children who passed the oral provocation test were instructed to take a prescribed dose of YQS when the temperature was >38.0℃ and continued till the fever settled. Time taken for fever resolution and any adverse events were collected.
RESULTS
A total of 21 children, mean age 10.7 years, had a diagnosis of paracetamol and ibuprofen hypersensitivity. All except one patient successfully tolerated an oral challenge of YQS. Of the 88 doses of YQS taken for fever over 38.0℃, 16 (18%) had documented temperature reduction 2 hours after ingestion and 30 (34%) had documented temperature reduction 4 hours after ingestion. There were 2 reports of urticaria after YQS use which were attributed to flare of recurrent spontaneous urticaria during the illness. None of the patients developed symptoms of circulatory compromise or respiratory distress.
CONCLUSION
YQS is generally well tolerated in patients with paracetamol and ibuprofen hypersensitivity.

Keyword

Child; Cyclooxygenase 1; Herbal Medicine; Hypersensitivity; Anti-Inflammatory Agents, Non-Steroidal; Acetaminophen

MeSH Terms

Acetaminophen
Anti-Inflammatory Agents, Non-Steroidal
Antipyretics
Asian Continental Ancestry Group
Child*
Cyclooxygenase 1
Diagnosis
Eating
Fever
Herbal Medicine
Humans
Hypersensitivity*
Ibuprofen
Pilot Projects*
Prospective Studies
Urticaria
Acetaminophen
Anti-Inflammatory Agents, Non-Steroidal
Antipyretics
Cyclooxygenase 1
Ibuprofen
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