Asia Pac Allergy.  2017 Jan;7(1):51-53. 10.5415/apallergy.2017.7.1.51.

Hypersensitivity to ticagrelor and low response to clopidogrel: a case report

• Dai J
• Lyu S
• Ge C

• KMID: 2396915
• DOI: http://doi.org/10.5415/apallergy.2017.7.1.51

Abstract

Ticagrelor is widely used to treat acute coronary syndrome. Hypersensitivity reaction of ticagrelor is rarely recognized. A low response to clopidogrel, which occurs in up to 23% of patients, is an independent risk factor for stent thrombosis. Management of patients with a low response to clopidogrel and ticagrelor hypersensitivity who are undergoing antithrombotic therapy remains to be a challenge. Herein, we report a patient with low response to clopidogrel and ticagrelor hypersensitivity, who was successfully managed using aspirin and warfarin.

Keyword

Antiplatelet therapy; Hypersensitivity; Low response; Ticagrelor; Clopidogrel; Warfarin

MeSH Terms

Acute Coronary Syndrome
Aspirin
Humans
Hypersensitivity*
Risk Factors
Stents
Thrombosis
Warfarin
Aspirin
Warfarin