Asia Pac Allergy.  2017 Jan;7(1):48-50. 10.5415/apallergy.2017.7.1.48.

Anaphylaxis caused by honey: a case report

  • 1Department Immunoallergology, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, E.P.E, 1649-035 Lisbon, Portugal.
  • 2Research and Development Department, Bial-Aristegui, Bilbao 48008, Spain.


Honey allergy is a very rare, but serious health condition. In this study, we presented 1 patient who had anaphylaxis after the honey allergological investigation with skin prick-prick test with honey. Honey as a food has been associated to allergic reactions and as the increased consumption of honey in health food may increase the incidence of honey-related allergic reactions.


Honey; Anaphylaxis; Prick-to-prick test

MeSH Terms



  • Fig. 1 Prick-prick tests with different kinds of honey.

  • Fig. 2 Sodium dodecyl sulfate-polyacrylamide gel electrophoresis immunoblotting: (A) honey A extract, (B) bee venom extract. Lane P, patient serum; lane C, control serum (pool of sera from nonatopic subjects); lane M, molecular mass standard.


1. Lombardi C, Senna GE, Gatti B, Feligioni M, Riva G, Bonadonna P, Dama AR, Canonica GW, Passalacqua G. Allergic reactions to honey and royal jelly and their relationship with sensitization to compositae. Allergol Immunopathol (Madr). 1998; 26:288–290.
2. Fuiano N, Incorvaia C, Riario-Sforza GG, Casino G. Anaphylaxis to honey in pollinosis to mugwort: a case report. Eur Ann Allergy Clin Immunol. 2006; 38:364–365.
3. Hofer T, Wüthrich B. Food allergy. II. Prevalence of organ manifestations of allergy-inducing food. A study on the basis of 173 cases, 1978-1982. Schweiz Med Wochenschr. 1985; 115:1437–1442.
4. Karakaya G, Fuat Kalyoncu A. Honey allergy in adult allergy practice. Allergol Immunopathol (Madr). 1999; 27:271–272.
5. Kalyoncu AF. Honey allergy and rhinitis in Ankara, Turkey. Allergy. 1997; 52:876–877.
6. Cifuentes L. Allergy to honeybee … not only stings. Curr Opin Allergy Clin Immunol. 2015; 15:364–368.
7. Katayama M, Aoki M, Kawana S. Case of anaphylaxis caused by ingestion of royal jelly. J Dermatol. 2008; 35:222–224.
8. Bauer L, Kohlich A, Hirschwehr R, Siemann U, Ebner H, Scheiner O, Kraft D, Ebner C. Food allergy to honey: pollen or bee products? Characterization of allergenic proteins in honey by means of immunoblotting. J Allergy Clin Immunol. 1996; 97(1 Pt 1):65–73.
Full Text Links
  • APA
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: