Asia Pac Allergy.  2017 Jan;7(1):42-47. 10.5415/apallergy.2017.7.1.42.

The impact of age on Pru p 3 IgE production in Italy

• Ciprandi G
• De Amici M
• Di Martino ML
• Barocci F
• Comite P

• KMID: 2396913
• DOI: http://doi.org/10.5415/apallergy.2017.7.1.42

Abstract

BACKGROUND
Pollen allergy may be frequently associated with fruit-vegetables: the so-called pollen food syndrome. Pru p 3 is the most relevant peach allergen. Previously, it has been reported that serum specific IgE level to Pru p 3 depends on age in a limited geographic area.
OBJECTIVE
This study aimed to to test the hypothesis about the differences of Pru p 3 sensitization across Italy, mainly concerning the impact of age.
METHODS
The current study was retrospective and multicentre, involving 2 labs in Northern Italy (709 subjects), 1 in Genoa (1,040 subjects), and 1 in Southern Italy (2,188 subjects). All of them referred to labs for IgE testing because of suspected food allergy. Serum IgE to Pru p 3 was assessed in all subjects.
RESULTS
Sixteen point seven percent (16.7%) of subjects were sensitized to Pru p 3. Sensitization percentage sigificantly decreased over time. The serum IgE levels increased up to young adulthood and then decreased until aging.
CONCLUSION
Our experience demonstrates that Pru p 3 sensitization and production are closely age-dependent phenomena.

Keyword

Pru p 3; Lipid transfer protein; Sensitization; Age; Italy

MeSH Terms

Aging
Food Hypersensitivity
Immunoglobulin E*
Italy*
Pollen
Prunus persica
Retrospective Studies
Rhinitis, Allergic, Seasonal
Immunoglobulin E

Figure

• 

  Fig. 1 Percentages of Pru p 3 sensitization according to age classes.

• 

  Fig. 2 Serum IgE levels to Pru p 3 according to age classes.

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