Korean J Dermatol.  2017 Nov;55(9):610-614.

A Case of Primary Cutaneous Anaplastic Large Cell Lymphoma on Palm

• Kim BS
• You MH
• Kim JG
• Kim YW
• Shin DH
• Choi JS

Abstract

Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare primary cutaneous lymphoma that is predominantly composed of large lymphoid cells that express the CD30 antigen. The skin lesion of PCALCL is usually single, ulcerative, and located on the trunk or extremities and rarely the palm. A 25-year-old woman presented with a plaque on the left palm for 20 days. The plaque was walnut-sized and purple to gray colored with erosion in the center. Histopathologic examination showed infiltration of large atypical cells in the dermis. The large tumor cells showed positivity for CD3, CD4, and CD30 and negativity for CD8, CD20, epithelial membrane antigen, and anaplastic lymphoma kinase. PET-CT showed no other hypermetabolic lesion except that on the left palm, and we finally arrived at a diagnosis of PCALCL. The patient was treated with an intralesional injection of methotrexate (25 mg/mL, 0.45 cc). After 3 months of treatment, the walnut-sized plaque had disappeared and a peripheral hyperpigmented patch remained.

Keyword

Anaplastic large cell lymphoma; Cutaneous lymphoma; Methotrexate

MeSH Terms

Adult
Antigens, CD30
Dermis
Diagnosis
Extremities
Female
Humans
Injections, Intralesional
Lymphocytes
Lymphoma
Lymphoma, Large-Cell, Anaplastic
Lymphoma, Primary Cutaneous Anaplastic Large Cell*
Methotrexate
Mucin-1
Phosphotransferases
Skin
Ulcer
Antigens, CD30
Methotrexate
Mucin-1
Phosphotransferases