Nucl Med Mol Imaging.  2017 Sep;51(3):252-255. 10.1007/s13139-016-0466-1.

Potential Adjunctive Role of Radiosynovectomy in Primary Synovial Osteochondromatosis of the Knee: A Case Report

  • 1Departments of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
  • 2Departments of Orthopedics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.


Primary synovial osteochondromatosis (PSOC) is a rare but clinically significant cause of morbidity especially in the male population. Surgery is the primary treatment of choice, but the recurrence rate is reported to be high. Moreover, the presence of widespread loose bodies makes it a cumbersome procedure. The complete removal of the disease is tough at times and results in early recurrence. Radiosynovectomy is an established technique for treating various joint arthropathies. The role of radiosynovectomy in case of PSOC has not yet been explored. This case report described the case of a young male with PSOC of the knee joint who was treated with radiosynovectomy for pain relief. The patient reported complete relief from the pain along with significant improvement in joint mobility. The post-therapy three-phase bone scan also validated the reduction in joint inflammation. The patient was taken for surgical removal of the redundant loose bodies after a significant improvement in the pain and reduction in inflammation. Post-therapy radiation fibrosis of the synovium also helped in the en bloc removal of the disease. The role of radiosynovectomy in PSOC needs to be further explored concerning its potential role as an adjuvant to surgical procedures.


Primary synovial osteochondromatosis (PSOC); Radiation synovectomy; Radiosynoviorthesis; Rhenium-188 (188Re)

MeSH Terms

Chondromatosis, Synovial*
Knee Joint
Radiation Pneumonitis
Synovial Membrane
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