J Liver Cancer.  2017 Sep;17(2):136-143. 10.17998/jlc.17.2.136.

Incidence of Primary Liver Cancer in Subjects with Chronic Hepatitis B in Korean National Liver Cancer Screening Program

Affiliations
  • 1Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea. joyshim@khu.ac.kr
  • 2Department of Radiology, Kyung Hee University School of Medicine, Seoul, Korea.
  • 3Department of Occupational and Environmental Medicine, Kyung Hee University School of Medicine, Seoul, Korea.

Abstract

BACKGROUND/AIMS
To optimize efficacy of National Liver Cancer Screening Program (NLCSP) for subjects with chronic hepatitis B (CHB), it is needed to know the incidence of liver cancer and its predisposing factors in the program.
METHODS
From January 2010 to December 2014, all the hepatitis B surface antigen (HBsAg) positive participants who received at least two or more abdominal ultrasonography under NLCSP were retrospectively enrolled in a single tertiary hospital. Annual incidence of primary liver cancer was calculated and related clinical factors were investigated.
RESULTS
During 5 years, 541 subjects were enrolled. Mean age was 53 years old and 292 subjects (54%) were receiving antiviral agents. Liver cirrhosis (LC) was diagnosed in 212 (39.2%). Mean follow-up time was 2.36 years and 15 hepatocellular carcinoma and 1 intrahepatic cholangiocarcinoma were diagnosed. Annual incidence of primary liver cancer was 9.8 per 1,000 patient year. Cumulative incidence at 1, 3, and 5 year was 0.6%, 2.6%, and 6.4%, respectively. In multivariate analyses, LC (hazard ratio [HR] 8.74, 95% confidence interval [CI] 1.97-38.71, P=0.024), age (HR 1.08, 95% CI 1.01-1.15, P=0.024) were significantly associated with cancer development.
CONCLUSIONS
Despite of high rate of oral antiviral therapy, incidence of primary liver cancer is not low in CHB patients in Korea. Old age and presence of LC are independently associated with higher risk of cancer development during surveillance. This study could be used as baseline data for quality control of NLCSP.

Keyword

Hepatocellular carcinoma; Hepatitis B, Chronic; Mass screening

MeSH Terms

Antiviral Agents
Carcinoma, Hepatocellular
Causality
Cholangiocarcinoma
Follow-Up Studies
Hepatitis B Surface Antigens
Hepatitis B, Chronic*
Hepatitis, Chronic*
Humans
Incidence*
Korea
Liver Cirrhosis
Liver Neoplasms*
Liver*
Mass Screening*
Multivariate Analysis
Quality Control
Retrospective Studies
Tertiary Care Centers
Ultrasonography
Antiviral Agents
Hepatitis B Surface Antigens
Full Text Links
  • JLC
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr