Yonsei Med J.  2008 Feb;49(1):63-70.

Increase of Metabolic Syndrome Score is an Independent Determinant of Increasing Pulse Pressure

• Moon JY
• Park S
• Ahn CM
• Cho JR
• Park CM
• Ko YG
• Choi D
• Jeong MH
• Jang Y
• Chung N

Abstract

PURPOSE
The objective of this study was to determine whether the progressive increase of metabolic syndrome (MetS) score, the number of components of MetS, is correlated significantly with increasing pulse pressure (PP). MATERIALS AND METHODS: 4,034 subjects were enrolled from the Cardiovascular Genome Center of Yonsei University (M:F=2344:1690, 55.2 +/- 10.5). Most of the study population were recruited from hypertension clinics, controlled with medications according to JNC7 guidelines. The Asian modified criteria of MetS were applied and MetS score was estimated. The HOMA index for insulin resistance, cholesterol profiles, and anthropometric measurements were assessed. RESULTS: Among 4034 participants, 1690 (41.9%) were classified as MetS. Progressive increase in PP was demonstrated for increasing components of the MetS score. Multiple linear regression analysis with PP as the dependent variable showed that age (beta=0.311, p < 0.001), MetS score (beta=0.226, p < 0.001), male gender (beta=-0.093, p < 0.001) and HOMA index IR (beta=0.033, p=0.03) are significantly associated with PP (R(2)=0.207, p < 0.001). CONCLUSION: The present results from this study demonstrate that increasing MetS score is an independent determinant of increasing PP. The results also demonstrate the independent role of MetS in increasing arterial stiffness and PP.

Keyword

Metabolic syndrome; pulse pressure; arterial stiffness; metabolic syndrome scores

MeSH Terms

Adult
Age Distribution
Aged
Blood Pressure
Female
Humans
Male
Metabolic Syndrome X/*epidemiology/physiopathology
Middle Aged

Figure

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  Fig. 1 Difference of pulse pressure in relation to metabolic syndrome score (Score 0: 36.8 ± 7.6; Score 1: 42.0 ± 12.1; Score 2: 45.2 ± 12.8; Score 3: 47.8 ± 14.2; Score 4: 50.5 ± 14.3; Score 5: 52.3 ± 16.9).

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  Fig. 2 Difference of pulse pressure in relation to metabolic syndrome score (in age groups).

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  Fig. 3 Difference of pulse pressure between HOMA 4 quartiles.

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