J Korean Ophthalmol Soc.
2017 Nov;58(11):1307-1312. 10.3341/jkos.2017.58.11.1307.
Hyper-proliferation of Glial Tissues Following Autologous Internal Limiting Membrane Transplantation in Idiopathic Large Macular Holes
- Affiliations
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- 1Department of Ophthalmology, Pusan National University Yangsan Hospital, Yangsan, Korea. isbyon@pusan.ac.kr
- 2Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
- 3Department of Ophthalmology, Pusan National University Hospital, Busan, Korea.
- 4Medical Research Institute, Pusan National University Hospital, Busan, Korea.
- 5Department of Ophthalmology, Pusan National University School of Medicine, Yangsan, Korea.
- KMID: 2395875
- DOI: http://doi.org/10.3341/jkos.2017.58.11.1307
Abstract
- PURPOSE
To report three cases of glial hyper-proliferation after autologous internal limiting membrane (ILM) transplantation in idiopathic large macular holes.
CASE SUMMARY
Three eyes with full thickness macular holes >500 µm underwent autologous ILM transplantation. After surgery, the macular hole was closed and foveal contour was U-shaped. Optical coherence tomography revealed long-lasting proliferation of glial cells in the fovea after the hole closure. This glial proliferation continued for 6 months, with improved visual acuity, and bump-like features of the fovea.
CONCLUSIONS
Autologous transplantation of ILM effectively induced long-lasting proliferation of glial cells, thereby achieving the closure of large macular holes. However, an abnormality of the foveal contour may develop after the hole closure in some cases.
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