J Korean Ophthalmol Soc.  2017 Nov;58(11):1242-1247. 10.3341/jkos.2017.58.11.1242.

24-hour Ambulatory Blood Pressure in Normal Tension Glaucoma: Associations with Retinal Vessel Diameter and Visual Field Defect Progression

Affiliations
  • 1Department of Ophthalmology, Konkuk University School of Medicine, Seoul, Korea. bjcho@kuh.ac.kr

Abstract

PURPOSE
To investigate the correlation between 24-hour ambulatory blood pressure (BP) monitoring and peripapillary retinal vessel width and visual field (VF) defect progression in normal tension glaucoma (NTG) patients.
METHODS
All patients were classified by 24-hour ambulatory BP monitoring as non-dipper (nocturnal dip < 10%) and dipper (nocturnal dip ≥ 10%) group. Vessel diameter, mean deviation (MD) value by VF test and VF progression from Glaucoma Progression Analysis (GPA) were compared among non-dipper and dipper groups.
RESULTS
Retinal arterial diameter was wider in the non-dipper group compared to the dipper group (p = 0.015), while retinal venous diameter had no significant relationship between the two groups (p = 0.131). The MD value at baseline and 2 years after was worse in the non-dipper group than the dipper group, respectively (p = 0.006, p = 0.030). But, there was no significant relationship between nocturnal dip and GPA progression (p = 0.658).
CONCLUSIONS
There was a statistically significant correlation between nocturnal dips and retinal arterial diameter and MD values. These results suggest that non-invasive fundus photography can predict hemodynamic features like nocturnal dip.

Keyword

Nocturnal dip; Normal tension glaucoma; Retinal vessel; Vessel narrowing; 24-hour ambulatory blood pressure monitoring

MeSH Terms

Blood Pressure*
Glaucoma
Hemodynamics
Humans
Low Tension Glaucoma*
Photography
Retinal Vessels*
Retinaldehyde*
Visual Fields*
Retinaldehyde

Figure

  • Figure 1 The geometric measurement of the retinal vessels. The 1 disc-diameter is marked as the white line based on the optic disc margin. All retinal vessel's diameter that cross the white line are measured two times by manual method then we selected the biggest 5 from arteries (A, red arrows) and veins (B, blue arrows).


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