Korean J Parasitol.  2017 Oct;55(5):561-564. 10.3347/kjp.2017.55.5.561.

First Case of Canine Infection with Hepatozoon canis (Apicomplexa: Haemogregarinidae) in the Republic of Korea

  • 1College of Veterinary Medicine, Chonbuk National University, Iksan 54596, Korea. uschoi@jbnu.ac.kr
  • 2Western Animal Medical Center, Seoul 04103, Korea.
  • 3Kwangjin Animal Medical Center, Seoul 04975, Korea.


This report describes a dog infected with Hepatozoon canis, the first canine infection in the Republic of Korea. A 2-year-old intact male Maltese dog presented with anorexia and depression. Physical examinations revealed mild dehydration and hyperthermia (39.8°C), and blood analysis showed pancytopenia. Diff-Quik staining of blood smear specimens showed the presence of ellipsoidal shaped structures (gamonts of H. canis) within a small number of neutrophils. Real-time PCR analysis using whole blood confirmed infection by H. canis. The clinical condition of the dog improved after symptomatic treatment and administration of doxycycline. Although a molecular epidemiologic survey in Korea showed H. canis infection of dogs, to our knowledge this is the first report of a dog infection in Korea molecularly shown to be H. canis.


Hepatozoon canis; hepatozoonosis; dog; Korea
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