Psychiatry Investig.  2017 Sep;14(5):687-692. 10.4306/pi.2017.14.5.687.

Genome-Wide Supported Risk Variants in MIR137, CACNA1C, CSMD1, DRD2, and GRM3 Contribute to Schizophrenia Susceptibility in Pakistani Population

• Fatima A
• Farooq M
• Abdullah U
• Tariq M
• Mustafa T
• Iqbal M
• Tommerup N
• Mahmood Baig S

• KMID: 2395494
• DOI: http://doi.org/10.4306/pi.2017.14.5.687

Abstract

OBJECTIVE
Schizophrenia is a chronic neuropsychiatric disease afflicting around 1.1% of the population worldwide. Recently, MIR137, CACNA1C, CSMD1, DRD2, and GRM3 have been reported as the most robustly emerging candidates involved in the etiology of schizophrenia. In this case control study, we performed an association analysis of rs1625579 (MIR137), rs1006737, rs4765905 (CACNA1C), rs10503253 (CSMD1), rs1076560 (DRD2), rs12704290, rs6465084, and rs148754219 (GRM3) in Pakistani population.
METHODS
Schizophrenia was diagnosed on the basis of the Diagnostic and Statistical Manual of Mental Disorders 4th ed (DSM-IV). Detailed clinical information, family history of all patients and healthy controls were collected. RFLP based case control association study was performed in a Pakistani cohort of 508 schizophrenia patients and 300 healthy control subjects. Alleles and genotype frequencies were calculated using SPSS.
RESULTS
A significant difference in the genotype and allele frequencies for rs4765905, rs1076560 and rs6465084 were found between the patients and controls (p=0.000).
CONCLUSION
This study provides substantial evidence supporting the role of CACNA1C, GRM3 and DRD2 as schizophrenia susceptibility genes in Pakistani population.

Keyword

Schizophrenia; MIR137; CACNA1C; CSMD1; GRM3; DRD2; Pakistan

MeSH Terms

Alleles
Case-Control Studies
Cohort Studies
Diagnostic and Statistical Manual of Mental Disorders
Gene Frequency
Genotype
Humans
Pakistan
Polymorphism, Restriction Fragment Length
Schizophrenia*