J Neurogastroenterol Motil.
2017 Oct;23(4):569-577. 10.5056/jnm17033.
Nationwide Multicenter Study for Overlaps of Common Functional Gastrointestinal Disorders in Korean Patients With Constipation
- Affiliations
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- 1Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
- 2Inje University College of Medicine, Busan, Korea.
- 3Pusan National University School of Medicine, Busan, Korea.
- 4Seoul National University College of Medicine, Seoul, Korea.
- 5Dankook University College of Medicine, Cheonan, Chungnam, Korea.
- 6Jeju National University School of Medicine, Jeju, Korea.
- 7Catholic University of Daegu School of Medicine, Daegu, Korea.
- 8Wonkwang University School of Medicine, Iksan, Jeonbuk, Korea. medcsc@wku.ac.kr
- 9Department of Internal Medicine and Wonkwang Digestive Disease Research Institute, Wonkwang University Sanbon Hospital, Gunpo, Gyeonggi-do, Korea.
- 10Kyungpook National University School of Medicine, Daegu, Korea.
- 11Soonchunhyang University College of Medicine, Seoul, Korea.
- 12Yeungnam University College of Medicine, Daegu, Korea.
- 13National Medical Center, Seoul, Korea.
- 14Chungnam National University School of Medicine, Daejeon, Korea.
- 15Hallym University College of Medicine, Chuncheon, Gangwon-do, Korea.
- 16Kosin University College of Medicine, Busan, Korea.
- 17Yonsei University College of Medicine, Seoul, Korea.
- 18Chonnam National University Medical School, Gwangju, Korea.
- 19Sungkyunkwan University School of Medicine, Seoul, Korea.
- KMID: 2395426
- DOI: http://doi.org/10.5056/jnm17033
Abstract
- BACKGROUND/AIMS
In spite of increased concerns about the overlaps among the various functional gastrointestinal disorders (FGIDs), studies for the overlap between constipation and other common FGIDs are rare. Therefore, we investigated the patterns of overlaps between constipation and other common FGIDs.
METHODS
This study was designed as a prospective nationwide multi-center questionnaire study using Rome III questionnaires for functional dyspepsia (FD), irritable bowel syndrome (IBS), and functional constipation (FC), as well as various questionnaires about patients' information, degree of symptoms, and quality of life. For the evaluation of gastroesophageal reflux disease (GERD), GERD-Q was used.
RESULTS
From 19 centers, 759 patients with constipation were enrolled. The proportions of FC and IBS subtypes of constipation (IBS-C) were 59.4% and 40.6%, respectively. Among them, 492 (64.8%) showed no overlap. One hundred and thirty-six patients (17.9%) presented overlapping GERD, and 80 patients (10.5%) presented overlapping FD. Fifty one (6.7%) of patients were overlapped by both GERD and FD. Coincidental herniated nucleus pulposus (HNP) (P = 0.026) or pulmonary diseases (P = 0.034), reduced fiber intake (P = 0.013), and laxative use (P < 0.001) independently affected the rate of overlaps. These overlapping conditions negatively affected the constipation-associated quality of life, general quality of life, and degree of constipation.
CONCLUSIONS
The overlap of GERD or FD was common in patients with constipation. Coincidental HNP or pulmonary diseases, reduced fiber intake, and laxatives use were found to be independent associated factors for overlapping common FGIDs in Korean patients with constipation.
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