Korean J Vet Res.  2017 Sep;57(3):175-180. 10.14405/kjvr.2017.57.3.175.

Evaluation of safety and immunogenicity of a new octavalent inactivated vaccine containing porcine parvovirus, erysipelas, and leptospira

• Kim K
• Choi JY
• Park SJ
• Hahn TW

• KMID: 2394908
• DOI: http://doi.org/10.14405/kjvr.2017.57.3.175

Abstract

Porcine parvovirus, Erysipelothrix (E.) rhusiopathiae, and Leptospira (L.) interrogans are considered major etiologic agents of reproductive failure in pigs, causing economic loss in the swine industry. In this study, the safety and immunogenicity of a new octavalent inactivated vaccine were evaluated. The vaccine contained inactivated porcine parvovirus, E. rhusiopathiae, and six L. interrogans serovars (Bratislava, Canicola, Grippotyphosa, Hardjo, Icterohaemorrhagiae, and Pomona). Safety test results showed no notable side effects or clinical signs after vaccination in mice, guinea pigs, and sows. In addition, we assessed immunogenicity of the vaccine in 25 sows under field conditions. The vaccinated group (n = 20) had a significantly higher antibody level than the non-vaccinated group (n = 5). Moreover, the stillbirth rate decreased in piglets born from vaccinated sows, resulting in an increased fertility rate. The results of this study demonstrate that the new octavalent inactivated vaccine can be applied safely and effectively to improve reproductive performance in sows.

Keyword

erysipelas; leptospirosis; porcine parvovirus; swine; vaccine

MeSH Terms

Animals
Birth Rate
Erysipelas*
Erysipelothrix
Guinea Pigs
Leptospira*
Leptospirosis
Mice
Parvovirus, Porcine*
Serogroup
Stillbirth
Swine
Vaccination