Ann Dermatol.  2017 Apr;29(2):249-251. 10.5021/ad.2017.29.2.249.

Glomeruloid Hemangioma as a Marker for the Early Diagnosis of POEMS Syndrome

• Lee JY
• Choi JK
• Ha JW
• Park SE
• Kim CW
• Kim SS

• KMID: 2394859
• DOI: http://doi.org/10.5021/ad.2017.29.2.249

Abstract

No abstract available.

MeSH Terms

Early Diagnosis*
Hemangioma*
POEMS Syndrome*

Figure

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  Fig. 1 (A) Multiple, bright red, dome-shaped papulonodular lesions of 2∼6-mm diameter were found scattered on the back and anterior chest. (B) Coarse hairs with surrounding brownish hyperpigmentation that were not previously present on the forearm, hand dorsum, and fingers were observed. (C) Schamroth's window test showed clubbed fingers with the loss of normal Lovibond angle.

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  Fig. 2 (A, B) The H&E-stained specimen at lower magnification indicates a polypoid nodule composed of numerous capillary loops and dilated vascular spaces resembling renal glomeruli (H&E; A:×40, B: ×100). (C) Eosinophilic hyaline globules within endothelial cells are stained with periodic acid-Schiff reagent at a higher magnification (PAS, ×200).

Reference

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2. Miest RY, Comfere NI, Dispenzieri A, Lohse CM, el-Azhary RA. Cutaneous manifestations in patients with POEMS syndrome. Int J Dermatol. 2013; 52:1349–1356.

3. Rho NK, Park SJ, Lee DY, Lee IS. A case of glomeruloid hemangioma in a patient with multicentric Castleman's disease. Ann Dermatol. 2002; 14:220–225.

4. Chan JK, Fletcher CD, Hicklin GA, Rosai J. Glomeruloid hemangioma. A distinctive cutaneous lesion of multicentric Castleman's disease associated with POEMS syndrome. Am J Surg Pathol. 1990; 14:1036–1046.

5. Gupta J, Kandhari R, Ramesh V, Singh A. Glomeruloid hemangioma in normal individuals. Indian J Dermatol. 2013; 58:160.