Ann Dermatol.  2017 Apr;29(2):229-232. 10.5021/ad.2017.29.2.229.

A Case of Primary Cutaneous Gamma-Delta T-Cell Lymphoma with Pautrier Microabscess

Affiliations
  • 1Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. tnamderm@tmd.ac.jp
  • 2Department of Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Abstract

No abstract available.


MeSH Terms

Lymphoma, T-Cell*
T-Lymphocytes*

Figure

  • Fig. 1 (A) Multiple erythematous tumors and plaques on the patient's trunk. The largest tumor was observed at the right lower abdomen. (B) Multiple erythematous tumors on the lower extremities.

  • Fig. 2 (A) Histology of a biopsy specimen of an erythematous plaque showing focal infiltrates of atypical lymphocytes in the dermis. The dotted boxes indicate the locations shown at higher magnification in Fig. 1B and 1C (H&E, ×20). (B) Infiltrates of atypical lymphocytes intermingled with histiocytes in the dermis (H&E, ×400). (C) Aggregations of atypical lymphocytes as Pautrier's microabscess in the epidermis (H&E, ×400). (D) Flow cytometry analyses of a biopsy specimen from the skin using a CD45/SSC gating procedure. CD45/SSC gated cells with various surface antigens of CD4, CD8, T-cell receptor (TCR)-αβ, TCR-γδ shown in two dot plots. (E) Immunohistochemistry of a biopsy specimen from the skin showing a positive reaction for CγM1 (×400). (F) Immunohistochemistry of a biopsy specimen from the skin showing a negative reaction for βF1 (×400). (G) Immunohistochemistry from a lymph node showing a positive reaction for CγM1 (×400).


Reference

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3. Rodríguez-Pinilla SM, Ortiz-Romero PL, Monsalvez V, Tomás IE, Almagro M, Sevilla A, et al. TCR-γ expression in primary cutaneous T-cell lymphomas. Am J Surg Pathol. 2013; 37:375–384.
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4. Guitart J, Weisenburger DD, Subtil A, Kim E, Wood G, Duvic M, et al. Cutaneous γδ T-cell lymphomas: a spectrum of presentations with overlap with other cytotoxic lymphomas. Am J Surg Pathol. 2012; 36:1656–1665.
5. Suga H, Sugaya M, Miyagaki T, Ohmatsu H, Fujita H, Sato S. Primary cutaneous γδ T-cell lymphoma following mycosis fungoides. Int J Dermatol. 2014; 53:e82–e84.
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