Osong Public Health Res Perspect.  2017 Aug;8(4):282-288. 10.24171/j.phrp.2017.8.4.09.

Seroprevalence of Brucellosis in Human Immunodeficiency Virus Infected Patients in Hamadan, Iran

• Keramat F
• Majzobi MM
• Poorolajal J
• Ghane ZZ
• Adabi M

• KMID: 2394487
• DOI: http://doi.org/10.24171/j.phrp.2017.8.4.09

Abstract

OBJECTIVES
Brucellosis is a systemic disease with a wide spectrum of clinical manifestations. This study aimed to determine the seroprevalence of brucellosis in human immunodeficiency virus (HIV) infected patients in Hamadan Province in the west of Iran.
METHODS
A total of 157 HIV-infected patients were screened through standard serological tests, including Wright's test, Coombs' Wright test, and 2-mercaptoethanol Brucella agglutination test (2ME test), blood cultures in Castaneda media, and CD4 counting. Data were analyzed using Stata version 11.
RESULTS
Wright and Coombs' Wright tests were carried out, and only 5 (3.2%) patients had positive serological results. However, all patients had negative 2ME results, and blood cultures were negative for Brucella spp. Moreover, patients with positive serology and a mean CD4 count of 355.8 ± 203.11 cells/μL had no clinical manifestations of brucellosis, and, and the other patients had a mean CD4 count of 335.55 ± 261.71 cells/μL.
CONCLUSION
Results of this study showed that HIV infection is not a predisposing factor of acquiring brucellosis.

Keyword

brucellosis; human immunodeficiency virus; serology

MeSH Terms

Agglutination Tests
Brucella
Brucellosis*
Causality
CD4 Lymphocyte Count
HIV Infections
HIV*
Humans*
Iran*
Mercaptoethanol
Seroepidemiologic Studies*
Serologic Tests
Mercaptoethanol