J Korean Ophthalmol Soc.  2017 Oct;58(10):1138-1144. 10.3341/jkos.2017.58.10.1138.

Intravitreal Bevacizumab Injections for Macular Edema Secondary to Major and Macular Branch Retinal Vein Occlusion

Affiliations
  • 1Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
  • 2Department of Ophthalmology, National Health Insurance Service Ilsan Hospital, Goyang, Korea. docchoi73@hanmail.net

Abstract

PURPOSE
To compare therapeutic outcome of intravitreal bevacizumab in treating macular edema between major and macular branch retinal vein occlusion (BRVO).
METHODS
This retrospective, observational study included 58 eyes from 58 patients with macular edema secondary to BRVO. All patients were treated with intravitreal bevacizumab injection at baseline, followed by further injections as required with monthly follow-up. Central foveal thickness and best-corrected visual acuity (BCVA) were evaluated after treatment between major and macular BRVO during 12 months of follow-up.
RESULTS
The mean best-corrected visual acuity (BCVA) in the major BRVO group (39 eyes), expressed as the logarithm of the minimum angle of resolution (logMAR), decreased from 0.66 ± 0.47 to 0.34 ± 0.28 after 12 months of treatment (p = 0.011). Similarly, in the macular BRVO group (19 eyes), the BCVA decreased from 0.60 ± 0.41 to 0.30 ± 0.22 (p = 0.014). The central foveal thickness decreased in the major BRVO group from 498.5 ± 194.3 µm to 311.3 ± 178.5 µm and in the macular BRVO group from 442.4 ± 155.8 µm to 297.2 ± 145.7 µm (p = 0.004 and 0.002, respectively). However, there was no significant difference between the groups with regard to either BCVA improvement or decrease in central foveal thickness. The mean injection number of macular BRVO (2.6 ± 1.6) was significantly lower than that of major BRVO (3.5 ± 1.4, p = 0.021).
CONCLUSIONS
The visual acuity improvement achieved after 12 months of intravitreal bevacizumab injection did not differ significantly between major and macular BRVO. However, significantly fewer injections were required for macular BRVO than major BRVO.

Keyword

Anti-vascular endothelial growth factor; Bevacizumab; Branch retinal vein occlusion; Macular edema

MeSH Terms

Bevacizumab*
Follow-Up Studies
Humans
Macular Edema*
Observational Study
Retinal Vein Occlusion*
Retinal Vein*
Retinaldehyde*
Retrospective Studies
Visual Acuity
Bevacizumab
Retinaldehyde

Figure

  • Figure 1. Patient's fundus photograph. (A) Fundus photograph of the right eye with superior temporal major branch retinal vein occlusion (BRVO). (B) Fundus photograph of the right eye with macular BRVO.

  • Figure 2. Changes of best-corrected visual acuity in logarithm of the minimal angle of resolution in eyes with macular edema secondary to branch retinal vein occlusion (BRVO). Although there was a significant improvement during the follow-up period in both major and macular BRVO groups, there was no statistical difference between major and macular BRVO groups in regard to visual outcome.

  • Figure 3. Changes in central foveal thickness in eyes with macular edema secondary to branch retinal vein occlusion (BRVO). The central foveal thickness was significantly improved after treatment in both groups. However, there was no difference at 12 months between major and macular BRVO groups.


Reference

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