Asian Spine J.  2017 Oct;11(5):706-714. 10.4184/asj.2017.11.5.706.

Comparison of Clinical and Radiological Outcomes of Lumbar Interbody Fusion Using a Combination of Hydroxyapatite and Demineralized Bone Matrix and Autografts for Lumbar Degenerative Spondylolisthesis

Affiliations
  • 1Department of Orthopaedic and Traumatology, Fatmawati General Hospital, South Jakarta, Indonesia. rizki.gatam@gmail.com
  • 2Department of Orthopaedic and Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine University of Indonesia, Central Jakarta, Indonesia.

Abstract

STUDY DESIGN: Prospective, cohort, non-inferiority study. PURPOSE: This study evaluated the clinical and radiological outcomes of interbody fusion using a combination of demineralized bone matrix (DBM) and hydroxyapatite (HA). OVERVIEW OF LITERATURE: The use of autografts remains a gold standard in lumbar interbody fusion, but the limited availability and donor site morbidity encourages the use of bone substitutes. In addition to autografts, a combination of HA and DBM is being increasingly use for lumbar interbody fusion. However, there are no data on the clinical and radiological outcomes of this procedure.
METHODS
We examined 35 patients with lumbar degenerative spondylolisthesis who underwent transforaminal interbody fusion. Autografts were used in 18 patients, and 17 patients received a combination of HA and DBM. Clinical outcomes were evaluated using the visual analog scale (VAS) for back and leg pain, Oswestry disability index (ODI), and Japanese Orthopaedic Association (JOA) scores at 3, 6, and 12 months postoperatively. Fusion was evaluated using computed tomography images obtained at 12 months postoperatively.
RESULTS
The mean ODI, JOA, and back and leg pain VAS scores increased significantly in both groups. However, the VAS, JOA, and ODI scores did not differ significantly between the two groups (p=0.599, p=0.543, and p=0.780, respectively). The fusion rates at 1 year postoperatively were 77.8% and 76.5% in the autograft and HA+DBM groups, respectively (p=0.99).
CONCLUSIONS
The clinical and radiological outcomes of using a combination of HA and DBM in lumbar interbody fusion were not inferior to those of using autografts. A combination of HA and DBM can be considered as an alternative in patients with lumbar degenerative spondylolisthesis requiring surgery.

Keyword

Lumbar; Spine fusion; Bone matrix; Hydroxyapatite; Lumbar degenerative spondylolisthesis

MeSH Terms

Asian Continental Ancestry Group
Autografts*
Bone Matrix*
Bone Substitutes
Cohort Studies
Durapatite*
Humans
Leg
Prospective Studies
Spondylolisthesis*
Tissue Donors
Visual Analog Scale
Bone Substitutes
Durapatite
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