Diabetes Metab J.  2017 Oct;41(5):393-404. 10.4093/dmj.2017.41.5.393.

Features of Long-Standing Korean Type 2 Diabetes Mellitus Patients with Diabetic Retinopathy: A Study Based on Standardized Clinical Data

Affiliations
  • 1Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea. jtwoomd@khmc.or.kr
  • 2Statistics Support Department, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Korea.
  • 3Department of Ophthalmology, Kyung Hee University School of Medicine, Seoul, Korea.

Abstract

BACKGROUND
This is part of a prospective study carried out as a national project to secure standardized public resources for type 2 diabetes mellitus (T2DM) patients in Korea. We compared various characteristics of long-standing T2DM patients with diabetic retinopathy (DR) and macular edema (ME).
METHODS
From September 2014 to July 2015, T2DM patients with disease duration of at least 15 years were recruited at a single university hospital. Clinical data and samples were collected according to the common data elements and standards of procedure developed by the Korean Diabetes Association Research Council. Each participant was assessed by ophthalmologists for DR and ME.
RESULTS
Among 220 registered patients, 183 completed the ophthalmologic assessment. DR was associated with longer disease duration (odds ratio [OR], 1.071; 95% confidence interval [CI], 1.001 to 1.147 for non-proliferative diabetic retinopathy [NPDR]) (OR, 1.142; 95% CI, 1.051 to 1.242 for proliferative diabetic retinopathy [PDR]) and the use of long-acting insulin (OR, 4.559; 95% CI, 1.672 to 12.427 for NPDR) (OR, 4.783; 95% CI, 1.581 to 14.474 for PDR), but a lower prevalence of a family history of cancer (OR, 0.310; 95% CI, 0.119 to 0.809 for NPDR) (OR, 0.206; 95% CI, 0.063 to 0.673 for PDR). ME was associated with higher glycosylated hemoglobin levels (OR, 1.380; 95% CI, 1.032 to 1.845) and the use of rapid-acting insulin (OR, 5.211; 95% CI, 1.445 to 18.794).
CONCLUSION
Various clinical features were associated with DR and ME. Additional epidemiological and biorepository-based studies using this cohort are being conducted to deepen our understanding of diabetic complications in Korea.

Keyword

Diabetes complications; Diabetes mellitus, type 2; Diabetic retinopathy; Macular edema

MeSH Terms

Cohort Studies
Common Data Elements
Diabetes Complications
Diabetes Mellitus, Type 2*
Diabetic Retinopathy*
Hemoglobin A, Glycosylated
Humans
Insulin, Long-Acting
Insulin, Short-Acting
Korea
Macular Edema
Prevalence
Prospective Studies
Insulin, Long-Acting
Insulin, Short-Acting

Figure

  • Fig. 1 Study participants.

  • Fig. 2 Odds ratio of diabetic retinopathy based on various demographic, lifestyle, social, and clinical factors. NPDR, non-proliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy; DM, diabetes mellitus; CI, confidence interval.

  • Fig. 3 Odds ratio of macular edema based on various demographic, lifestyle, social, and clinical factors. CI, confidence interval.


Cited by  2 articles

Relationship between Clinical Features of Diabetic Retinopathy and Systemic Factors in Patients with Newly Diagnosed Type II Diabetes Mellitus
Hyeseong Hwang, Jin Young Kim, Tae Keun Oh, Ju Byung Chae, Dong Yoon Kim
J Korean Med Sci. 2020;35(23):e179.    doi: 10.3346/jkms.2020.35.e179.

Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis
Seung-Hyun Ko, Kyungdo Han, Yong-ho Lee, Junghyun Noh, Cheol-Young Park, Dae-Jung Kim, Chang Hee Jung, Ki-Up Lee, Kyung-Soo Ko,
Diabetes Metab J. 2018;42(2):93-100.    doi: 10.4093/dmj.2018.42.2.93.


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