Diabetes Metab J.  2017 Oct;41(5):327-336. 10.4093/dmj.2017.41.5.327.

Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism

• Periasamy
• Herrera JL
• Reis FC

• KMID: 2392475
• DOI: http://doi.org/10.4093/dmj.2017.41.5.327

Abstract

Obesity and diabetes has become a major epidemic across the globe. Controlling obesity has been a challenge since this would require either increased physical activity or reduced caloric intake; both are difficult to enforce. There has been renewed interest in exploiting pathways such as uncoupling protein 1 (UCP1)-mediated uncoupling in brown adipose tissue (BAT) and white adipose tissue to increase energy expenditure to control weight gain. However, relying on UCP1-based thermogenesis alone may not be sufficient to control obesity in humans. On the other hand, skeletal muscle is the largest organ and a major contributor to basal metabolic rate and increasing energy expenditure in muscle through nonshivering thermogenic mechanisms, which can substantially affect whole body metabolism and weight gain. In this review we will describe the role of Sarcolipin-mediated uncoupling of Sarcoplasmic Reticulum Calcium ATPase (SERCA) as a potential mechanism for increased energy expenditure both during cold and diet-induced thermogenesis.

Keyword

ATP hydrolysis; Calcium cycling; Diabetes mellitus; Obesity; Sarcolipin; Sarcoplasmic reticulum calcium-transporting ATPases; Skeletal muscle thermogenesis

MeSH Terms

Adipose Tissue, Brown
Adipose Tissue, White
Basal Metabolism
Diabetes Mellitus
Energy Intake
Energy Metabolism*
Hand
Humans
Metabolism
Motor Activity
Muscle, Skeletal*
Obesity
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Thermogenesis*
Weight Gain
Sarcoplasmic Reticulum Calcium-Transporting ATPases