Allergy Asthma Respir Dis.  2017 Sep;5(5):256-261. 10.4168/aard.2017.5.5.256.

Effect of atopic dermatitis on the natural course of food allergy in infants and young children

Affiliations
  • 1Department of Pediatrics, Inha University Hospital, Incheon, Korea. kimjhmd@inha.ac.kr
  • 2The Environmental Health Center for Allergic Rhinitis, Inha University Hospital, Incheon, Korea.
  • 3Research Institute for Healthcare Policy, Korean Medical Association, Seoul, Korea.

Abstract

PURPOSE
There have been studies showing that food allergy plays a role in the pathogenesis of atopic dermatitis. However, there have been few studies about the effect of atopic dermatitis on remission of food allergy. Thus, this study aimed to evaluate the difference in remission according to the presence of atopic dermatitis in infants and young children with milk or egg allergy.
METHODS
A retrospective study was performed on 109 infants and young children with IgE-mediated food allergy in a tertiary hospital. They divided into food allergy with atopic dermatitis (FA with AD) and without atopic dermatitis (FA without AD).
RESULTS
In the milk allergy group, initial milk-specific IgE levels were 21.16±27.98 kU(A)/L and 11.36±22.88 kU(A)/L, respectively, in FA with AD and FA without AD under 12 months of age. The remission rates of milk allergy at 36 months of age were 64.9% and 90.0%, respectively, in FA with AD and FA without AD. In the egg allergy groups, initial egg-specific IgE levels were 34.48±36.72 kU(A)/L and 15.66±28.60 kU(A)/L, respectively, in FA with AD and FA without AD under 12 months of age. The remission rates of egg allergy at 36 months of age were 61.2% and 90.0% in children with FA with AD and FA without AD.
CONCLUSION
Atopic dermatitis may play an important role in the natural history of food allergy in infants. Different strategies are needed for the management of food allergy in young children with atopic dermatitis.

Keyword

Food hypersensitivity; Egg hypersensitivity; Milk hypersensitivity; Atopic dermatitis

MeSH Terms

Child*
Dermatitis, Atopic*
Egg Hypersensitivity
Food Hypersensitivity*
Humans
Immunoglobulin E
Infant*
Milk
Milk Hypersensitivity
Natural History
Retrospective Studies
Tertiary Care Centers
Immunoglobulin E

Figure

  • Fig. 1. Subgroups of subjects. FA, food allergy, AD, atopic dermatitis.

  • Fig. 2. Remission rate of milk allergy at 36 months of age. FA, food allergy; AD, atopic dermatitis.

  • Fig. 3. Remission rate of egg allergy at 36 months of age. FA, food allergy; AD, atopic dermatitis.


Cited by  2 articles

Clinical and Laboratory Predictors of Egg Allergy Resolution in Children
Jeong Hee Kim
Allergy Asthma Immunol Res. 2019;11(4):446-449.    doi: 10.4168/aair.2019.11.4.446.

Factors related with the natural course of food allergy
So-Yeon Lee
Allergy Asthma Respir Dis. 2017;5(5):237-238.    doi: 10.4168/aard.2017.5.5.237.


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