Allergy Asthma Respir Dis.  2017 Mar;5(2):99-104. 10.4168/aard.2017.5.2.99.

Correlation between serum cytokines and clinical feature of children with mild lower respiratory infection

• Kim GJ
• Park YM
• Won SM
• Choi SJ
• Kim HS
• Chun YH
• Yoon JS
• Kim HH
• Kim JT

• KMID: 2392381
• DOI: http://doi.org/10.4168/aard.2017.5.2.99

Abstract

PURPOSE
Acute lower respiratory infection (ALRI), which is frequently encountered in pediatric patients, is the leading cause of hospitalization. We aimed to identify particular cytokines that correlated with ALRI clinical characteristics. We also aimed to identify any differences in cytokines between respiratory syncytial virus (RSV)-related ALRI and non-RSV-related ALRI.
METHODS
Cytokine levels were measured in the sera sampled from 103 pediatric patients diagnosed with ALRI and admitted to Seoul St. Mary's Hospital between May 2012 and April 2013. The correlations between cytokine levels and the length of hospitalization, the number of days with fever, body temperature, pulse rate, respiration rate, oxygen saturation upon admission, and duration of oxygen supplementation were analyzed.
RESULTS
In children with ALRI, the level of interleukin (IL)-6, granulocyte-colony stimulating factor (G-CSF), and IL-10 were correlated with a higher body temperature on admission. In addition, the IL-8 level was correlated with pulse rate and respiration rate, and IL-1β level was related with oxygen saturation on admission. In children with RSV-related ALRI, the IL-6 was correlated the with duration of fever, and the IL-1β, IL-2, and IL-8 levels were related to pulse rate and respiration rate. In addition, the increase in interferon-gamma-inducible protein-10 (IP-10) level was correlated with a higher body temperature on admission and a longer duration of hospitalization in children with RSV-related ALRI.
CONCLUSION
In children with ALRI, the levels of IL-6, IL-8, IL-1β, G-CSF, and IP-10 were correlated with its clinical features. In children with RSV-related ALRI, the IL-1β, IL-2, IL-6, IL-8, and IP-10 level was correlated with the severity of the disease.

Keyword

Child; Cytokines; Lower respiratory infection

MeSH Terms

Body Temperature
Child*
Cytokines*
Fever
Granulocyte Colony-Stimulating Factor
Heart Rate
Hospitalization
Humans
Interleukin-10
Interleukin-2
Interleukin-6
Interleukin-8
Interleukins
Oxygen
Respiratory Rate
Respiratory Syncytial Viruses
Seoul
Cytokines
Granulocyte Colony-Stimulating Factor
Interleukin-10
Interleukin-2
Interleukin-6
Interleukin-8
Interleukins
Oxygen