Korean J Med.  2017 Aug;92(4):342-348. 10.3904/kjm.2017.92.4.342.

Controversies Regarding the New Definition of Sepsis

Affiliations
  • 1Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
  • 2Division of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea. pugae1@korea.ac.kr

Abstract

The Third International Consensus Definitions for Sepsis and Septic Shock (SEPSIS-3) task force assessed the latest pathophysiological parameters associated with sepsis and septic shock and defined sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection. This SEPSIS-3 definition may be applied using relevant clinical and biological criteria including changes in the Sequential Organ Failure Assessment score and serum lactate levels. The new definition does not include criteria for systemic inflammatory response syndrome or the concept of 'severe sepsis.' The SEPSIS-3 definition aims to devise more precise descriptions of sepsis and to improve clinical care. However, there are important questions relating to the clinical application of the new definition. We review the main characteristics and limitations of previous definitions and discuss some of the potential controversies raised by the new framework.

Keyword

Sepsis; Shock, Septic; Organ dysfunction scores; Systemic inflammatory response syndrome

MeSH Terms

Advisory Committees
Consensus
Lactic Acid
Organ Dysfunction Scores
Sepsis*
Shock, Septic
Systemic Inflammatory Response Syndrome
Lactic Acid
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