J Korean Endocr Soc.  2006 Dec;21(6):490-496.

Comparison of Common Carotid Artery Intima-Media Thickness between Subclinical Hypothyroidism and Euthyroidism

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Pochon CHA University, Korea.

Abstract

BACKGROUND: Common carotid artery intima-media thickness (IMT), which is increased in patients with overt hypothyroidism, is an independent risk factor of the atherosclerosis-related disease. This study was performed to compare serum lipid level and common carotid artery IMT among patients with overt hypothyroidism, subclinical hypothyroidism and euthyroidism.
METHODS
Patients with newly-diagnosed subclinical (n=32) and overt (n=32) hypothyroidism were selected for this study. All of the patients and an age- and sex-matched euthyroidism cohort were checked for clinical characteristics and serum lipid levels. Common carotid artery IMT was also measured using high resolution B-mode ultrasonography.
RESULTS
Statistically significant differences were observed between the total cholesterol levels of patients with subclinical hypothyroidism and those with euthyroidism. When common carotid artery IMT measured by ultrasonography, subclinical (0.67 +/- 0.11 mm) and overt (0.71 +/- 0.12 mm)) hypothyroidism showed significantly increased mean IMT compared to that of euthyroidism (0.58 +/- 0.07 mm, P < 0.05, respectively), but no differences were found between subclinical and overt hypothyroidism.
CONCLUSION
We concluded that subclinical hypothyroidism is related to increased common carotid artery IMT as well as dyslipidemia. Therefore, we recommend that treatment principle of subclinical hypothyroidism be established through large-scale, prospective studies performed to determine the effect of thyroid hormone replacement on the reduction of common carotid artery IMT.

Keyword

Atherosclerosis; Intima-media thickness; Subclinical hypothyroidism

MeSH Terms

Atherosclerosis
Carotid Artery, Common*
Cholesterol
Cohort Studies
Dyslipidemias
Humans
Hypothyroidism*
Risk Factors
Thyroid Gland
Ultrasonography
Cholesterol

Figure

  • Fig. 1 Common carotid artery intima-media thickness of the study population. *P < 0.05 (one-way ANOVA followed by Scheffe's post hoc test). IMTmean, mean intima-media thickness; IMTmax, maximal intima-media thickness.


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