Infect Chemother.  2017 Sep;49(3):227-229. 10.3947/ic.2017.49.3.227.

MALDI-TOF-MS Fingerprinting Provides Evidence of Urosepsis caused by Aerococcus urinae

  • 1Department of Laboratory Medicine, Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea.


Urosepsis due to Aerococcus urinae is rare in clinical settings with only a few of reported cases worldwide by 16S rRNA sequencing. Here we report a case of sepsis caused by A. urinae in a 86 year-old male with complicated urinary tract infection which was confirmed through peptide mass fingerprinting of matrix-assisted laser desorption ionization time of flight mass spectrometry.


Urosepsis; Aerococcus urinae; Matrix-assisted laser desorption ionization time of flight mass spectrometry

MeSH Terms

Mass Spectrometry
Urinary Tract Infections


  • Figure 1 (A) Peptide mass fingerprinting by MALDI-TOF-MS of Aerococcus urinae from blood culture; (B) peptide mass fingerprinting by MALDI-TOF-MS of A. urinae from urine culture. MALDI-TOF-MS, matrix-assisted laser desorption ionization time of flight mass spectrometry.


1. Wagenlehner FM, Lichtenstern C, Rolfes C, Mayer K, Uhle F, Weidner W, Weigand MA. Diagnosis and management for urosepsis. Int J Urol. 2013; 20:963–970.
2. Rosenthal EJ. Epidemiology of septicaemia pathogens. Dtsch Med Wochenschr. 2002; 127:2435–2440.
3. Schuur PM, Kasteren ME, Sabbe L, Vos MC, Janssens MM, Buiting AG. Urinary tract infections with Aerococcus urinae in the south of The Netherlands. Eur J Clin Microbiol Infect Dis. 1997; 16:871–875.
4. de Jong MF, Soetekouw R, ten Kate RW, Veenendaal D. Aerococcus urinae: severe and fatal bloodstream infections and endocarditis. J Clin Microbiol. 2010; 48:3445–3447.
5. Colakoglu S, Turunc T, Taskoparan M, Aliskan H, Kizilkilic E, Demiroglu YZ, Arslan H. Three cases of serious infection caused by Aerococcus urinae: a patient with spontaneous bacterial peritonitis and two patients with bacteremia. Infection. 2008; 36:288–290.
6. Schuur PM, Sabbe L, van der Wouw AJ, Montagne GJ, Buiting AG. Three cases of serious infection caused by Aerococcus urinae. Eur J Clin Microbiol Infect Dis. 1999; 18:368–371.
7. Clinical and Laboratory Standards Institute (CLSI). Interpretive criteria for identification of bacteria and fungi by DNA target sequencing: approved guideline. Wayne, PA: CLSI;2008.
8. Senneby E, Nilson B, Petersson AC, Rasmussen M. Matrix-assisted laser desorption ionization-time of flight mass spectrometry is a sensitive and specific method for identification of aerococci. J Clin Microbiol. 2013; 51:1303–1304.
9. Sørensen SM, Schønheyder HC, Nielsen H. The role of imaging of the urinary tract in patients with urosepsis. Int J Infect Dis. 2013; 17:e299–e303.
10. Sturm PD, Van Eijk J, Veltman S, Meuleman E, Schülin T. Urosepsis with Actinobaculum schaalii and Aerococcus urinae. J Clin Microbiol. 2006; 44:652–654.
Full Text Links
  • IC
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: