Korean J Crit Care Med.  2017 Aug;32(3):302-305. 10.4266/kjccm.2017.00108.

An Ofloxacin-Induced Anaphylaxis through an IgG4-Mediated but Not IgE-Mediated Basophil Activation Mechanism

Affiliations
  • 1Division of Pulmonology and Allergy, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea.
  • 2Division of Allergy and Pulmonology, Chungmu Hospital, Cheonan, Korea.
  • 3Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. hspark@ajou.ac.kr

Abstract

No abstract available.


MeSH Terms

Anaphylaxis*
Basophils*

Figure

  • Figure 1. Detection of serum specific IgG4 antibodies to ofloxacin-human serum albumin (HSA) conjugate by ELISA from the patient (●) and 20 non-atopic normal controls (○). OD: optical density; ELISA: enzyme-linked immunosorbent assay.

  • Figure 2. Results of basophil activation test with addition of ofloxacin-human serum albumin (HSA) conjugate (A) and anti-IgG4 antibodies (B) in the patient (●) and three healthy controls (◇, △, ∇).


Reference

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