Pediatr Infect Vaccine.  2017 Apr;24(1):37-43. 10.14776/piv.2017.24.1.37.

Clinical Characteristics of Pertussis Epidemic in Changwon

  • 1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, the Republic of Korea.
  • 2Department of Pediatrics, Changwon Fatima Hospital, Changwon, the Republic of Korea.


Pertussis can be prevented with a vaccine. Despite this, there have been an increasing number of cases worldwide, and also in Korea. This study aimed to investigate the epidemiology and clinical characteristics of the recent outbreak in the Changwon area.
Patients who visited Changwon Fatima Hospital from July 2015 to March 2016 with respiratory symptoms, including spasmodic cough, cough induced vomiting, inspiratory "˜intake' sound (whooping), and a night-time cough for >1 week were included in this study. Respiratory specimens were collected from patients and a polymerase chain reaction (PCR) and detected anti-pertussis immunoglobulin G enzyme-linked immunosorbent assay kit test were performed. Patients with underlying diseases, or those who had received a DTaP or Tdap vaccination in recent 1 year were excluded.
Pertussis was diagnosed in 37 of 50 patients, two patients were positive according to the PCR, and 37 patients were positive according to serologic tests. The age distribution of the patients was 1 month to 15 years. After administering antibiotics, all patients recovered without complications.
A pertussis outbreak occurred in Changwon in 2015 and 2016. This data can provide the basis for further study on the epidemiology of pertussis in Korea.


Whooping cough; Polymerase chain reaction; Enzyme-linked immunosorbent assay
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