J Gastric Cancer.  2017 Sep;17(3):277-281. 10.5230/jgc.2017.17.e22.

Plexiform Angiomyxoid Myofibroblastic Tumor of the Stomach: a Rare Case

Affiliations
  • 1Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jmoon.bae@samsung.com
  • 2Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

Plexiform angiomyxoid myofibroblastic tumor (PAMT) of the stomach is a very rare mesenchymal tumor of the gastrointestinal tract. We report a case of asymptomatic gastric PAMT that was pathologically confirmed after surgical resection. The tumor had a multinodular plexiform growth pattern, bland-looking spindle cells, and an Alcian blue-positive myxoid stromal matrix rich in small blood vessels. Immunohistochemistry analysis revealed that the tumor cells of the PAMT were positive for smooth muscle actin (SMA) and negative for c-kit, CD34, S-100 protein, epithelial membrane antigen (EMA), and desmin. PAMT should be differentiated from other submucosal tumors of the stomach by immunohistochemical findings. Considering the benign features of this tumor, observation without resection may be an option for the treatment of PAMT if the tumor is asymptomatic.

Keyword

Stomach; Neoplasms; Mesenchymal tumor

MeSH Terms

Actins
Blood Vessels
Desmin
Gastrointestinal Tract
Immunohistochemistry
Mucin-1
Muscle, Smooth
Myofibroblasts*
S100 Proteins
Stomach*
Actins
Desmin
Mucin-1
S100 Proteins
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