Korean J Leg Med.  2017 Aug;41(3):83-85. 10.7580/kjlm.2017.41.3.83.

Death Related to Nitrous Oxide Abuse: Two Cases Report

Affiliations
  • 1Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 2Division of Forensic Investigation, National Forensic Service Seoul Institute, Seoul, Korea. ecc88@korea.kr

Abstract

Nitrous oxide is medically used as an anesthetic gas and as an additive in whipped cream production. Few cases of death from nitrous oxide intoxication have been reported in Korea. However, fatalities due to inhalation of pure nitrous oxide in an amount enough to cause death have been recently increasing. We report two cases of death related to nitrous oxide abuse with a review of literature focusing on the fact that nitrous oxide abuse can be considered as a possible cause of death if appliances with nitrous oxide contents were found during the investigation, and the autopsy and toxicological findings cannot be attributed to nitrous oxide intoxication.

Keyword

Nitrous oxide; Inhalant abuse; Death; Autopsy; Toxicology

MeSH Terms

Autopsy
Cause of Death
Inhalant Abuse
Inhalation
Korea
Nitrous Oxide*
Toxicology
Nitrous Oxide

Reference

1. Potocka-Banas B, Majdanik S, Dutkiewicz G, et al. Death caused by addictive inhalation of nitrous oxide. Hum Exp Toxicol. 2011; 30:1875–1877.
2. Kunkel DB. The toxic emergency, nitrous oxide: not a laughing matter anymore. Emerg Med. 1987; 9:79–84.
3. Sugimura M, Hanamoto H, Boku A, et al. Influence of acute hypoxia combined with nitrous oxide on cardiovascular variability in conscious hypertensive rats. Auton Neurosci. 2010; 156:73–81.
4. Ohyama M, Oka K, Adachi S, et al. Effects of nitrous acid exposure on pulmonary tissues in guinea pigs. Inhal Toxicol. 2010; 22:930–936.
5. Weimann J. Toxicity of nitrous oxide. Best Pract Res Clin Anaesthesiol. 2003; 17:47–61.
6. Backstrom B, Johansson B, Eriksson A. Death from nitrous oxide. J Forensic Sci. 2015; 60:1662–1665.
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