Ann Dermatol.  2017 Oct;29(5):543-547. 10.5021/ad.2017.29.5.543.

Pulsed Dye Laser Treatment Combined with Oral Minocycline Reduces Recurrence Rate of Rosacea

Affiliations
  • 1Department of Dermatology, Inha University School of Medicine, Incheon, Korea. mikie2001@hanmail.net
  • 2Department of Biomedical Sciences, Inha University School of Medicine, Incheon, Korea.

Abstract

BACKGROUND
The recurrence rate of rosacea was not known very well, but has been reported as 60% in 6 months after withdrawal of the drug. It is not known which treatment can reduce relapses of rosacea effectively.
OBJECTIVE
The objective was to identify whether 595 nm-pulsed dye laser (PDL) treatment reduced recurrence rate among rosacea patients who were treated with oral minocycline.
METHODS
One hundred and seven Korean patients with rosacea who started treatment with oral minocycline (100 mg/d) with or without PDL (2∼4 sessions) were evaluated retrospectively. The recurrence rate was estimated using the Kaplan-Meier method, and difference was evaluated using the log-rank test. Cox proportional hazards model was used to estimate hazard ratios and 95% confidence intervals (CIs) of risk factors for the recurrence of rosacea.
RESULTS
The recurrence-free survival analysis revealed that the group with oral minocycline plus PDL was significantly different compared with the group with oral minocycline alone (p=0.011). Cox proportional hazards model showed that the combined use of PDL with oral minocycline appeared to be a significant protective factor for the hazard of recurrence of rosacea (hazard ratio, 0.492; 95% CI, 0.257∼0.941; p=0.032).
CONCLUSION
PDL can be used added to oral minocycline to reduce relapses among rosacea patients who are undergoing oral minocycline treatment.

Keyword

Minocycline; Pulsed dye laser; Recurrence; Rosacea; Therapeutics

MeSH Terms

Humans
Lasers, Dye*
Methods
Minocycline*
Proportional Hazards Models
Protective Factors
Recurrence*
Retrospective Studies
Risk Factors
Rosacea*
Minocycline

Figure

  • Fig. 1 The Kaplan-Meier curve showing recurrence for all patients. The overall recurrence-free survival analysis revealed that group 1 was significantly different compared with group 2 (p=0.011). MC: minocycline, PDL: pulsed dye laser, Group 1: oral minocycline (100 mg per day) alone, Group 2: oral minocycline (100 mg per day) plus 595 nm-PDL (total 2∼4 sessions). *p<0.05.


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