Korean J Dermatol.  2013 Jun;51(6):465-469.

A Case of Cutaneous Rosai-Dofman Disease Treated with Isotretinoin and Pulsed Dye Laser

• Han J
• Kim JE
• Park GH
• Won CH
• Chang SE
• Lee MW
• Choi JH
• Moon KC

Abstract

Rosai-Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy (SMHL) is a benign histiocytic proliferative disorder of unknown etiology. The disease is usually accompanied by massive bilateral lymphadenopathy, fever, elevated erythrocyte sedimentation rate, leukocytosis with neutrophilia, and polyclonal hypergammaglobulinemia. Histopathologic examinations showed characteristically large histiocytes exhibiting emperipolesis. On immunohistochemical stains, histiocytes are positive for CD68 and S-100 protein, but negative for CD1a. The lymph node involvement is typical, but it may also involve other systemic organs in one third of the cases such as skin, upper respiratory tract, bones and so on. Patients with purely cutaneous Rosai-Dorfman diseases are of older age at onset of the disease with a reversed male/female ratio, thus, cutaneous Rosai-Dorfman disease is recognized as a distinct entity from the Rosai-Dorfman disease. Herein, we present a 50-year-old man with erythematous papules and indurated plaques on both cheeks, diagnosed as cutaneous Rosai-Dorfman disease. The lesions were treated with isotretinoin 10 mg bid for 9 months with pulsed dye laser.

Keyword

Isotretinoin; Pulsed dye laser; Rosai-Dorfman disease

MeSH Terms

Blood Sedimentation
Cheek
Coloring Agents
Emperipolesis
Fever
Histiocytes
Histiocytosis, Sinus
Humans
Hypergammaglobulinemia
Isotretinoin
Lasers, Dye
Leukocytosis
Lymph Nodes
Lymphatic Diseases
Respiratory System
S100 Proteins
Skin
Coloring Agents
Isotretinoin
S100 Proteins