J Neurogastroenterol Motil.  2017 Jul;23(3):392-399. 10.5056/jnm16173.

Prevalence of Gastric Motility Disorders in Patients with Functional Dyspepsia

• Asano H
• Tomita T
• Nakamura K
• Yamasaki T
• Okugawa T
• Kondo T
• Kono T
• Tozawa K
• Ohda Y
• Oshima T
• Fukui H
• Fukushima
• Hirota S
• Watari J
• Miwa H

• KMID: 2387830
• DOI: http://doi.org/10.5056/jnm16173

Abstract

BACKGROUND/AIMS
Gastric motility abnormalities have been considered to be pathophysiological features of functional dyspepsia (FD) that are closely related to dyspepsia symptoms, especially postprandial distress syndrome (PDS). The aims of this study are to (1) investigate the prevalence of gastric motility disorders and (2) evaluate the association between gastric motility abnormalities and dyspeptic symptoms using gastric scintigraphy in the PDS type of FD.
METHODS
Forty healthy subjects and 94 PDS type FD patients were enrolled in the study. The volunteers and patients ingested a radiolabeled (technetium-99m) solid test meal, and scintigraphic images were recorded. Gastric accommodation and emptying were assessed by scintigraphic imaging. The patients' dyspeptic symptoms were also explored using self-completed symptom questionnaires with 10 variables (4 scales, 0-3 points) at the same time.
RESULTS
In 94 Japanese FD patients, the prevalence of impaired gastric accommodation and delayed emptying were 14.9% (14/94) and 10.6% (10/94), respectively. Gastric motility abnormalities were seen in 25.5% (24/94) of FD patients. There was no association between gastric motility abnormalities and dyspeptic symptoms.
CONCLUSIONS
Gastric motility abnormalities were seen in 25.5% of Japanese PDS type FD patients. However, there was no association between gastric motility abnormalities and dyspeptic symptoms on gastric scintigraphy.

Keyword

Dyspepsia; Motility; Prevalence; Stomach

MeSH Terms

Asian Continental Ancestry Group
Dyspepsia*
Healthy Volunteers
Humans
Meals
Prevalence*
Radionuclide Imaging
Stomach
Volunteers
Weights and Measures