Allergy Asthma Respir Dis.  2017 Jul;5(4):223-227. 10.4168/aard.2017.5.4.223.

Serum micronutrients levels and clinical features of elderly asthmatics

  • 1Departement of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
  • 2Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.
  • 3Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 4Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
  • 5Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
  • 6Department of Internal Medicine, Chosun University Medical School, Gwangju, Korea.
  • 7Department of Allergy and Clinical Immunology, Asan Medical Center, Seoul, Korea.
  • 8Department of Internal Medicine, Samsung Medical Center, Seoul, Korea.
  • 9Department of Internal Medicine, Dankook University College of Medicine, Choenan, Korea.
  • 10Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.


The prevalence of asthma in the elderly is rapidly increasing. However, we do not fully understand the pathogenesis of elderly asthma, especially for the roles of micronutrients. This study aimed to evaluate the associations between serum levels of micronutrients, including several vitamins and minerals, and clinical features of the elderly asthmatics.
A total of 317 asthmatics aged 65 or older were enrolled. Serum levels of vitamin D, vitamin B₁₂, folate, Mg, and Se were measured and then the associations between serum micronutrient levels and clinical features of elderly asthmatics were evaluated.
Positive correlations with significance among serum levels of vitamin B₁₂, vitamin D, and folate were found. Serum micronutrients levels showed no difference according to the atopic status and symptom severity. The serum folate level was significantly associated with forced expiratory volume in 1 second, and serum vitamin B₁₂ and folate levels were significantly associated with serum total IgE level. Interestingly, elderly asthmatics with exacerbation history showed significantly lower serum levels of vitamin D and Mg, but significantly higher serum levels of Se.
Serum levels of micronutrients, such as vitamin D, vitamin B₁₂, Mg, folate, and Se, were significantly associated with some clinical features of elderly asthmatics. Clinical meanings of these associations need to be investigated further.


Elderly; Asthma; Micronutrients
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