Allergy Asthma Respir Dis.  2017 Jul;5(4):185-192. 10.4168/aard.2017.5.4.185.

The KAAACI Standardization Committee Report on the procedure and application of fractional exhaled nitric oxide measurement

Affiliations
  • 1Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.
  • 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. swj0126@gmail.com
  • 3Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
  • 4Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam, Korea.
  • 5Department of Internal Medicine, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, Korea.
  • 6Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
  • 7Department of Pediatrics, Yonsei University Wonju College of Medicine, Wonju, Korea.
  • 8Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
  • 9Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
  • 10Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 11Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
  • 12Division of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

Fractional exhaled nitric oxide (FeNO) is a biomarker for type 2 inflammation in the airways, and its measurement has the distinct strengths of being simple, rapid, convenient, and reproducible. Since the discovery of FeNO in the 1990s, its measurement tools have been extensively developed and validated by several researchers. In particular, FeNO showed the potential to support the diagnosis of asthma and eosinophilic bronchitis. Since it has begun to be widely utilized in clinical research areas as well as daily practice, we summarized the standardized diagnostic procedures and suggested the clinical application of FeNO measurement in Korean population.

Keyword

Nitric oxide; Diagnostic techniques and procedures; Asthma; Reference standards
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