Psychiatry Investig.  2017 Jul;14(4):420-426. 10.4306/pi.2017.14.4.420.

Clinical Dementia Rating Orientation Score as an Excellent Predictor of the Progression to Alzheimer's Disease in Mild Cognitive Impairment

• Kim JW
• Byun MS
• Sohn BK
• Yi D
• Seo EH
• Choe YM
• Kim SG
• Choi HJ
• Lee JH
• Chee IS
• Woo JI
• Lee DY

• KMID: 2387132
• DOI: http://doi.org/10.4306/pi.2017.14.4.420

Abstract

OBJECTIVE
This study aimed to examine the usefulness of each subscale score of the Clinical Dementia Rating (CDR) for predicting Alzheimer's disease (AD) dementia progression in amnestic mild cognitive impairment (MCI) elderly subjects.
METHODS
Fifty-nine elderly MCI individuals were recruited from a university dementia and memory disorder clinic. Standardized clinical and neuropsychological tests were performed both at baseline and at the time of 2 years follow-up. Logistic regression analyses were conducted to examine the ability of various clinical measures or their combinations to predict progression to AD dementia in MCI individuals.
RESULTS
MCIp individuals showed significantly higher CDR Orientation subscale and CDR sum-of-boxes (SOB) score than MCInp ones, while there were no significant differences in other CDR subscale scores between the two. MCIp individuals also showed marginally higher MMSE scores than MCInp ones. A series of logistic regression analyses demonstrated that the model including CDR Orientation subscale had better AD dementia prediction accuracy than either the model with either MMSE or CDR-SOB.
CONCLUSION
Our findings suggest that CDR Orientation subscale score, a simple and easily available clinical measure, could provide very useful information to predict AD dementia progression in amnestic MCI individuals in real clinical settings.

Keyword

Mild cognitive impairment; Alzheimer's disease; Clinical Dementia Rating,; Orientation; Prediction

MeSH Terms

Aged
Alzheimer Disease*
Dementia*
Follow-Up Studies
Humans
Logistic Models
Memory Disorders
Mild Cognitive Impairment*
Neuropsychological Tests