J Genet Med.  2017 Jun;14(1):38-42. 10.5734/JGM.2017.14.1.38.

Prenatal diagnosis of 4p deletion syndrome: A case series report

Affiliations
  • 1Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea. hyunkyong.ahn@gmail.com

Abstract

The 4p deletion syndrome, also known as Wolf-Hirschhorn syndrome, is a well-known genetic disorder caused by a partial deletion of the short arm of chromosome 4. The great variability in the extent of the 4p deletion and the possible contribution of additional genetic rearrangements leads to a wide spectrum of clinical manifestations. Herein, we present our experience with eight cases of 4p deletion syndrome, ascertained prenatally between 1998 and 2016 at our hospital.

Keyword

Wolf-Hirschhorn syndrome; 4p deletion; Prenatal diagnosis
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