Ewha Med J.  2017 Jul;40(3):128-135. 10.12771/emj.2017.40.3.128.

Characteristics for Ischemic Stroke in 18–30 Years Old Patients, Multicenter Stroke Registry Study

• Chang Y
• Song TJ
• Kim YJ
• Heo JH
• Lee KY
• Kim YE
• Jang MU
• Cho SJ
• Kang SY

• KMID: 2386390
• DOI: http://doi.org/10.12771/emj.2017.40.3.128

Abstract

OBJECTIVES
Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18-30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry.
METHODS
We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke.
RESULTS
The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42-15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3).
CONCLUSION
In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

Keyword

Young age stroke; Cerebral infarction; Carotid artery, internal, dissection; Vertebral artery dissection; Undetermined negative etiology; Prognosis

MeSH Terms

Carotid Artery, Internal, Dissection
Cerebral Infarction
Demography
Humans
Male
National Institutes of Health (U.S.)
Prognosis
Prospective Studies
Stroke*
United Nations
Vertebral Artery Dissection

Figure

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  Fig. 1. Stroke subtype comparison for very young age (18–30 years old) with young age (31–44 years old) or above young age (≥45 years old). Values are presented as number (%). The stroke of other determined etiology and undetermined negative evaluation stroke subtype were more frequently noted in 18–30 years old patients than those of 31–44 years old and ≥45 years old. The frequency of large artery atherosclerosis and small vessel occlusion subtypes was increased in elderly groups (31–44 years old and ≥45 years old groups; P=0.001).

Reference

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