J Lipid Atheroscler.  2017 Jun;6(1):39-45. 10.12997/jla.2017.6.1.39.

Survival Rates in Peripheral Artery Disease

• Jang SY
• Park SW
• Kim YW
• Kim DK

• KMID: 2385843
• DOI: http://doi.org/10.12997/jla.2017.6.1.39

Abstract

OBJECTIVE
The aim of this study was to analyze the long-term survival of subjects with peripheral artery disease (PAD).
METHODS
The data included 415 Korean PAD patients aged ≥20 years hospitalized from 1994 through 2004 at a single tertiary center in Korea. Death data were obtained from all participants between 1994 and 2009.
RESULTS
The mean of age was 64.4±9.3 years in PAD. The proportion of peripheral vascular bypass operation (re-vascularized) was about 50%. The proportion of males was 90.6% in PAD. Five- and 10- year survival rates were 79.2% and 60.5% in PAD, respectively. The 5- and 10- year survival rates were 83.0% and 64.1% in re-vascularized group, and 75.5% and 56.3% in non-revascularized group (p<0.05). For PAD, the adjusted hazard ratios (HRs) were 1.75 (95% confidence interval (CI) 1.17-2.68) in over 65 years, 1.53 (95% CI 1.05-2.27) in diabetes, and 2.21 (95% CI 1.51-3.23) in chronic kidney disease (CKD). Interestingly, HRs in PAD were 0.55 (95% CI 0.34-0.84) in overweight and 0.45 (95% CI 0.25-0.76) in obesity.
CONCLUSIONS
The 5- and 10- year survival rates were 79.2% and 60.5% in PAD. The survival rate in re-vascularized group was higher than that in non-revascularized group. Independent predictors of mortality were age, diabetes, and CKD in PAD. Obesity showed improved survival rates.

Keyword

Peripheral artery disease; Survival rates

MeSH Terms

Humans
Korea
Male
Mortality
Obesity
Overweight
Peripheral Arterial Disease*
Renal Insufficiency, Chronic
Survival Rate*

Figure

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  Fig. 1. (A) Cumulative survival rates of the peripheral artery disease (PAD) group and (B) cumulative survival rates with revascularization or not in PAD using Kaplan-Meier curves.

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  Fig. 2. (A) Cumulative survival rates by over 65 years old and under with peripheral artery disease (PAD) using Kaplan-Meier curves (p<0.001), (B) cumulative survival rates by gender with PAD using Kaplan-Meier curves (p<0.001), (C) cumulative survival rates in hypertension (HT) patients with PAD using Kaplan-Meier curves (p<0.001), (D) cumulative survival rates in diabetes mellitus (DM) patients with PAD using Kaplan-Meier curves (p<0.001), (E) cumulative survival rates in dyslipidemia patients with PAD using Kaplan-Meier curves (p<0.001), (F) cumulative survival rates in smoker with PAD using Kaplan-Meier curves (p<0.001)

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