J Korean Soc Transplant.  2017 Jun;31(2):59-67. 10.4285/jkstn.2017.31.2.59.

A Preliminary Study to Revise the Marginal Donor Criteria of KONOS in Deceased Donor Kidney Transplantation

Affiliations
  • 1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. wooseong.huh@samsung.com

Abstract

BACKGROUND
The Korean Network for Organ Sharing (KONOS), which was established in December 31st, 1999, is a nationwide system of deceased donor detection and distribution. From its inception, KONOS has defined marginal donors and used this definition for over 15 years. However, this definition should be reevaluated to determine if it requires revision. This study was conducted to confirm the feasibility of the main study for revision of the marginal donor definition in deceased donor kidney transplantation.
METHODS
This study is a retrospective meta-analysis of 786 patients who had deceased donor kidney transplant from six centers. After the data validation process, multivariable analysis was conducted to evaluate whether the marginal donor criteria of KONOS or UNOS expected adequately in terms of graft survival and delayed graft function (DGF).
RESULTS
Neither the KONOS or UNOS criteria affected graft survival. Expanded criteria for donors of UNOS was a risk factor for DGF. However, KONOS criteria did not affect DGF.
CONCLUSIONS
Based on this preliminary study, there is a need to conduct a study to revise the marginal donor criteria of KONOS in deceased donor kidney transplantation. Such a study should have large scale and long-term follow-up data.

Keyword

Organ donor; Brain death; Kidney transplantation

MeSH Terms

Brain Death
Delayed Graft Function
Follow-Up Studies
Graft Survival
Humans
Kidney Transplantation*
Kidney*
Retrospective Studies
Risk Factors
Tissue Donors*

Reference

1. Korean Network for Organ Sharing (KONOS). 2015 Annual data report [Internet]. Seoul: KONOS;2016. cited 2016 Oct 21. Available from: http://konos.go.kr.
2. Global Observatory on Donation and Transplantation (GODT). Total rate (pmp) total number of actual deceased organ donor (Global. 2014) [Internet]. GODT;2016. cited 2016 Oct 20. Available from: http://transplant-observatory.org.
3. Matesanz R, Dominguez-Gil B, Coll E, de la Rosa G, Marazuela R. Spanish experience as a leading country: what kind of measures were taken? Transpl Int. 2011; 24:333–343.
Article
4. Salim A, Ley EJ, Berry C, Schulman D, Navarro S, Zheng L, et al. Increasing organ donation in Hispanic Americans: the role of media and other community outreach efforts. JAMA Surg. 2014; 149:71–76.
5. Doyle MB, Vachharajani N, Wellen JR, Lowell JA, Shenoy S, Ridolfi G, et al. A novel organ donor facility: a decade of experience with liver donors. Am J Transplant. 2014; 14:615–620.
Article
6. van Smaalen TC, Hoogland ER, van Heurn LW. Machine perfusion viability testing. Curr Opin Organ Transplant. 2013; 18:168–173.
Article
7. Marrero WJ, Naik AS, Friedewald JJ, Xu Y, Hutton DW, Lavieri MS, et al. Predictors of deceased donor kidney discard in the United States. Transplantation. [in press 2016 May 10].
Article
8. Rosengard BR, Feng S, Alfred EJ, Zaroff JG, Emond JC, Henry ML, et al. Report of the Crystal city meeting to maximize the use of organ recovered from the cadaver donor. Am J Transplant. 2002; 2:701–711.
Article
9. Korean Network for Organ Sharing (KONOS). 2016 Business guide on organ transplant management [Internet]. Seoul: KONOS;2016. cited 2016 Oct 21. Available from: http://konos.go.kr.
10. United Network for Organ Sharing (UNOS). Questions and answers for transplant candidates about kidney allocation [Internet]. Richmond, Va: UNOS;2016. cited 2016 Oct 11. Available from: http://www.unos.org.
11. Park UJ, Cho WH, Kim HT, Kim MY, Kim YL, Kim CD, et al. Evaluation of the Korean Network for Organ Sharing expanded donor criteria in deceased renal transplantation. J Korean Soc Transplant. 2013; 27:166–173.
Article
12. Yang SS, Yang J, Ahn C, Min SI, Ha J, Kim SJ, et al. The need for new donor stratification to predict graft survival in deceased donor kidney transplantation. Yonsei Med J. 2017; 58:626–630.
Article
13. Frei U, Noeldeke J, Machold-Fabrizil V, Arbogast H, Margreiter R, Fricke L, et al. Prospective age-matching in elderly kidney transplant recipients-a 5-year analysis of the Eurotransplant Senior Program. Am J Transplant. 2008; 8:50–57.
Article
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