Nutr Res Pract.  2017 Aug;11(4):327-333. 10.4162/nrp.2017.11.4.327.

Effects of folic acid supplementation on serum homocysteine levels, lipid profiles, and vascular parameters in post-menopausal Korean women with type 2 diabetes mellitus

Affiliations
  • 1Department of Nutritional Science and Food Management, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea. nschang@ewha.ac.kr
  • 2Huh's Diabetes Clinics & 21C Diabetes and Vascular Research Institute, Seoul 04101, Korea.

Abstract

BACKGROUND/OBJECTIVES
Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. Homocysteine has been recently identified as a predictor of cardiovascular disease-related complications in diabetes. We investigated whether or not supplementation with folic acid tablets can lower homocysteine levels and improve parameters related with vascular complications.
SUBJECTS/METHODS
We conducted a non-randomized 8-week trial involving postmenopausal diabetic women (n = 25) supplemented with 800 µg of folic acid (400 µg twice a day) daily. Subjects' serum levels of folate, homocysteine, and vitamin B₁₂ were measured, along with vascular function and brachial-ankle pulse wave velocity.
RESULTS
Folic acid supplementation significantly increased serum folate levels (P < 0.0001), reduced homocysteine levels (P < 0.0001), and increased vitamin B₁₂ levels (P = 0.0063). There were significant decreases in low-density lipoprotein cholesterol levels as well as the ratios of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol and total cholesterol to high-density lipoprotein cholesterol. Brachial-ankle pulse wave velocities were not altered by supplementation. Changes in serum vitamin B₁₂ after folic acid supplementation were negatively correlated with changes in brachial-ankle pulse wave velocity.
CONCLUSIONS
In this study on postmenopausal Korean women with type 2 diabetes mellitus, folic acid supplementation reduced serum homocysteine levels, increased serum folate and vitamin B₁₂ levels, and lowered lipid parameters.

Keyword

Folic acid; vitamin B₁₂; LDL cholesterol; pulse wave velocity

MeSH Terms

Cardiovascular Diseases
Cholesterol
Cholesterol, LDL
Diabetes Mellitus, Type 2*
Female
Folic Acid*
Homocysteine*
Humans
Lipoproteins
Mortality
Pulse Wave Analysis
Tablets
Vitamin B 12
Vitamins
Cholesterol
Cholesterol, LDL
Folic Acid
Homocysteine
Lipoproteins
Tablets
Vitamin B 12
Vitamins
Full Text Links
  • NRP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error