J Korean Med Assoc.  2017 Jun;60(6):499-505. 10.5124/jkma.2017.60.6.499.

Saphenous vein occlusion with cyanoacrylate: a systematic review

Affiliations
  • 1Division for New Health Technology Assessment, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea. shkim@neca.re.kr

Abstract

Saphenous vein occlusion with cyanoacrylate is a new technology for the treatment of incompetent veins by endovascular embolization with cyanoacrylate glue. The objective of this review was to evaluate the safety and effectiveness of saphenous vein occlusion with cyanoacrylate. A literature search was conducted using 8 Korean databases, Medline, Embase, and the Cochrane Library. From the 1,730 articles that were initially identified, 8 studies (1 randomized controlled trial, 1 non-randomized controlled trial, and 6 case series/case reports) were included in this review. The results show that similar levels of adverse events or complications occurred in patients treated with cyanoacrylate ablation compared to the other treatment groups (laser ablation or radiofrequency ablation), but the ecchymosis and closure rates of the treated veins were significantly better in the cyanoacrylate ablation group. Improvements in symptoms and quality of life after the treatment were also observed. On the basis of the current data, saphenous vein occlusion with cyanoacrylate can be recommended as a safe and effective treatment for patients with saphenous vein reflux.

Keyword

Cyanoacrylate; Saphenous vein; Varicose veins; Systematic review

MeSH Terms

Adhesives
Cyanoacrylates*
Ecchymosis
Humans
Quality of Life
Saphenous Vein*
Varicose Veins
Veins
Adhesives
Cyanoacrylates

Figure

  • Figure 1 Flow chart of literature selection process.


Reference

1. Alm J. VenaSeal closure treatment of saphenous varicosis. Phlebologie. 2014; 43:242–248.
Article
2. Almeida JI, Javier JJ, Mackay EG, Bautista C, Cher DJ, Proebstle TM. Two-year follow-up of first human use of cyanoacrylate adhesive for treatment of saphenous vein incompetence. Phlebology. 2015; 30:397–404.
Article
3. Anwar MA, Lane TR, Franklin IJ, Davies AH. Cyanoacrylate for the treatment of small saphenous vein venous incompetence. Cureus. 2014; 6:e221.
Article
4. Bozkurt AK, Yılmaz MF. A prospective comparison of a new cyanoacrylate glue and laser ablation for the treatment of venous insufficiency. Phlebology. 2016; 31:1 Suppl. 106–113.
Article
5. Calik ES, Arslan U, Ayaz F, Tort M, Yildiz Z, Aksu V, Onk OA, Limandal HK, Ekingen E, Dag O, Kaygin MA, Erkut B. N-butyl cyanoacrylate in the treatment of venous insufficiency: the effect of embolisation with ablative polymerisation. Vasa. 2016; 45:241–246.
Article
6. Cho DY. Treatment of varicose vein. J Korean Med Assoc. 2010; 53:1006–1014.
Article
7. Jang JY. Prevention and management of gastroesophageal varices. Korean J Med. 2008; 75:6–14.
8. Kim HK. New trend of the varicose veins. J Korean Med Assoc. 2003; 46:1097–1104.
Article
9. Lane TR, Kelleher D, Moore HM, Franklin IJ, Davies AH. Cyanoacrylate glue for the treatment of great saphenous vein incompetence in the anticoagulated patient. J Vasc Surg Venous Lymphat Disord. 2013; 1:298–300.
Article
10. Lee Y. Recent development of chemical adhesives for medical applications. Polym Sci Technol. 2014; 25:402–410.
11. Morrison N, Gibson K, McEnroe S, Goldman M, King T, Weiss R, Cher D, Jones A. Randomized trial comparing cyanoacrylate embolization and radiofrequency ablation for incompetent great saphenous veins (VeClose). J Vasc Surg. 2015; 61:985–994.
Article
12. Proebstle TM, Alm J, Dimitri S, Rasmussen L, Whiteley M, Lawson J, Cher D, Davies A. The European multicenter cohort study on cyanoacrylate embolization of refluxing great saphenous veins. J Vasc Surg Venous Lymphat Disord. 2015; 3:2–7.
Article
13. Song SY. A theoretical study on approach on skin & beauty in the treatment of lower extremities varix. Korean J Aesthet Cosmetol. 2003; 1:95–101.
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