Clin Endosc.  2016 Nov;49(6):564-569. 10.5946/ce.2016.020.

Multidrug-Resistant Tuberculous Mediastinal Lymphadenitis, with an Esophagomediastinal Fistula, Mimicking an Esophageal Submucosal Tumor

• Kim D
• Kim J
• Lee D
• Chang HS
• Joh H
• Koh WJ
• Lee JH

• KMID: 2383454
• DOI: http://doi.org/10.5946/ce.2016.020

Abstract

Mediastinal tuberculous lymphadenitis rarely mimics esophageal submucosal tumor, particularly in the case of multidrug-resistant tuberculosis (MDR-TB). Herein, we report the case of a 61-year-old woman who visited a local hospital complaining of odynophagia. An initial esophagogastroduodenoscopy revealed an esophageal submucosal tumor, and subsequent chest computed tomography showed subcarinal lymphadenopathy with an esophagomediastinal fistula. The patient was then referred to Samsung Medical Center, and a second esophagogastroduodenoscopy showed deep central ulceration, as well as a suspicious fistula in the esophageal submucosal tumor-like lesion. A biopsy examination of the ulcerative lesion confirmed focal inflammation only. Next, an endobronchial, ultrasound-guided lymph node biopsy was performed, and TB was confirmed. The patient initially began a course of isoniazid, rifampicin, ethambutol, and pyrazinamide. However, after a drug sensitivity test, she was diagnosed with MDR-TB, and second-line anti-TB medications were prescribed. She recovered well subsequently.

Keyword

Tuberculosis; Lymphadenitis; Esophageal fistula

MeSH Terms

Biopsy
Endoscopy, Digestive System
Esophageal Fistula
Ethambutol
Female
Fistula*
Humans
Inflammation
Isoniazid
Lymph Nodes
Lymphadenitis*
Lymphatic Diseases
Middle Aged
Pyrazinamide
Rifampin
Thorax
Tuberculosis
Tuberculosis, Lymph Node
Tuberculosis, Multidrug-Resistant
Ulcer
Ethambutol
Isoniazid
Pyrazinamide
Rifampin