Ann Dermatol.  2011 Nov;23(4):544-547.

Sibutramine (Reductil(R))-Induced Cutaneous Leukocytoclastic Vasculitis: A Case Report

• Ha YJ
• Han YJ
• Choi YW
• Myung KB
• Choi HY

Abstract

A 24-year old woman presented with hemorrhagic vesicles on her legs. She had taken sibutramine (Reductil(R), Abbott Labs., Seoul, South Korea) for 3 months and developed skin lesions the week before. A skin biopsy showed leukocytoclastic vasculitis with conspicuous eosinophilic infiltration of the tissue. These lesions showed improvement after discontinuation of sibutramine. However, 3 months later the skin lesions recurred on other sites on the lower extremities when the patient was rechallenged with the same drug for 2 weeks. Herein, we report the first case of necrotizing vasculitis induced by sibutramine.

Keyword

Cutaneous leukocytoclastic vasculitis; Drug induced vasculitis; Sibutramine

MeSH Terms

Biopsy
Cyclobutanes
Eosinophils
Female
Humans
Leg
Lower Extremity
Skin
Vasculitis
Vasculitis, Leukocytoclastic, Cutaneous
Cyclobutanes
Vasculitis, Leukocytoclastic, Cutaneous