Ann Dermatol.  2011 Nov;23(4):493-496.

Bowenoid Papulosis of the Vulva and Subsequent Periungual Bowen's Disease Induced by the Same Mucosal HPVs

• Shim WH
• Park HJ
• Kim HS
• Kim SH
• Jung DS
• Ko HC
• Kim BS
• Kim MB
• Kwon KS

Abstract

We report the case of a 23-year-old woman who developed bowenoid papulosis of the vulva and subsequent periungual Bowen's disease. She had a history of a long standing periungual wart on her right thumb before the outbreak of periungual Bowen's disease. By HPV DNA chip, human papillomavirus (HPV) 11, 18 and 31 were identified from the periungual lesions, and HPV 11, 18 and 33 from the vulvar lesion. This case supports the theory of anogenital-digital spread of HPV, and proposes that the periungual wart may change into Bowen's disease by mucosal HPVs. To the best of our knowledge, this case is important as the first Korean case of periungual Bowen's disease concurrent with bowenoid papulosis of the vulva.

Keyword

Bowen disease; Human papillomavirus

MeSH Terms

Bowen's Disease
Female
Human papillomavirus 11
Humans
Oligonucleotide Array Sequence Analysis
Thumb
Vulva
Warts
Young Adult

Figure

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  Fig. 1 (A) Multiple pigmented verrucous papules and plaques on the periungual area for 4 months. (B) Hyperpigmented verrucous plaques on the genital area for 7 months.

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  Fig. 2 (A) The biopsy specimen from the periungual lesion shows severe cytologic atypia (nuclear enlargement, hyperchromasia, and pleomorphism), numerous mitoses, and scattered dyskeratotic cells (H&E, ×100). (B) The biopsy specimen from the vulvar lesion shows full-thickness atypia and dyskeratosis (H&E, ×100).

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  Fig. 3 The HPV DNA chip was amplified from the human papillomavirus (HPV) polymerase chain reaction and subsequently hybridized to oligonucleotide probes specific to each genotype. (A) The positive signal was represented as double spots. (B) Combined infections of HPV type 11, 18 and 31 in periungual lesion. (C) Combined infections of HPV type 11, 18 and 33 in vulvar lesion.

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