Ann Dermatol.  2016 Oct;28(5):629-631. 10.5021/ad.2016.28.5.629.

Pedunculated Nodules as a Variant of Dermatofibrosarcoma Protuberans

• Kim MJ
• Hur MS
• Choi BG
• Kim SY
• Lee YW
• Choe YB
• Ahn KJ

• KMID: 2382889
• DOI: http://doi.org/10.5021/ad.2016.28.5.629

Abstract

Dermatofibrosarcoma protuberans (DFSP) is a rare disease of dermal fibroblastic origin that accounts for less than 5% of all soft tissue sarcomas in adults. DFSP grows slowly and is an asymptomatic lesion at the initial diagnosis. Herein, we report a case of multiple pedunculated nodules as a variant of DFSP. A 47-year-old man presented with a 7-month history of multiple well-circumscribed, firm, pedunculated nodules on the inguinal area. Histopathologic examination results showed densely packed uniform spindle cells with a storiform and cartwheel pattern, and positivity for CD34. Wide excision and skin graft were performed and at the 6-month follow-up, there was no evidence of recurrence or metastasis.

Keyword

Dermatofibrosarcoma protuberans; Multiple pedunculated nodules

MeSH Terms

Adult
Dermatofibrosarcoma*
Diagnosis
Fibroblasts
Follow-Up Studies
Humans
Middle Aged
Neoplasm Metastasis
Rare Diseases
Recurrence
Sarcoma
Skin
Transplants

Figure

• 

  Fig. 1 Multiple well-circumscribed, firm, pedunculated nodules on the inguinal area.

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  Fig. 2 (A) Densely packed, uniform spindle cells with a storiform and cartwheel pattern (H&E, ×40). (B) The spindle cells spread into subcutis layer with honeycomb-like appearance (H&E, ×100). (C) Immunohistochemistry results showing uniform positivity for CD34 (CD34, ×200).

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