Korean J Intern Med.  2015 Nov;30(6):759-770. 10.3904/kjim.2015.30.6.759.

Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation

Affiliations
  • 1Transplant Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 2Convergent Research Consortium for Immunologic Disease, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 3Division of Nephrology, Department of Internal Medicine, Yanbian University Hospital, Yanji, China. lican@ybu.edu.cn

Abstract

Despite strict pre- and post-transplantation screening, the incidence of new-onset diabetes after transplantation (NODAT) remains as high as 60%. This complication affects the risk of cardiovascular events and patient and graft survival rates. Thus, reducing the impact of NODAT could improve overall transplant success. The pathogenesis of NODAT is multifactorial, and both modifiable and nonmodifiable risk factors have been implicated. Monitoring and controlling the blood glucose profile, implementing multidisciplinary care, performing lifestyle modifications, using a modified immunosuppressive regimen, administering anti-metabolite agents, and taking a conventional antidiabetic approach may diminish the incidence of NODAT. In addition to these preventive strategies, inhibition of dipeptidyl peptidase-4 (DPP4) by the gliptin family of drugs has recently gained considerable interest as therapy for type 2 diabetes mellitus and NODAT. This review focuses on the role of DPP4 inhibitors and discusses recent literature regarding management of NODAT.

Keyword

Kidney transplantation; New-onset diabetes after transplantation; Dipeptidyl-peptidase IV inhibitors
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