J Pathol Transl Med.  2015 May;49(3):243-248. 10.4132/jptm.2015.03.30.

Smad1 Expression in Follicular Lymphoma

Affiliations
  • 1Department of Pathology, Dankook University College of Medicine, Cheonan, Korea. cyjy555@ hanmail.net

Abstract

BACKGROUND
Follicular lymphomas present with various immunohistologic patterns. The immunohistochemical markers used in the diagnosis of follicular lymphoma show variable degrees of sensitivity and specificity, and thus, additional germinal center markers are required. Smad1 has been reported to be overexpressed in follicular lymphoma, but little is known regarding the expression patterns of Smad proteins in human lymphoid tissue.
METHODS
In the present study, we performed immunohistochemistry for traditional germinal center markers and for Smad1 in human reactive lymphoid and follicular lymphoma tissues to investigate Smad1's usefulness in the diagnosis of follicular lymphoma.
RESULTS
In the reactive germinal centers, most cells were positive for Smad1. Among the 27 follicular lymphoma cases, 17 of 21 (80%) were Smad1 positive, 17 of 27 (63%) were positive for CD10, and 23 of 27 (85%) were positive for Bcl6. Notably, three cases expressed CD10 only, and one only expressed Bcl6. All these cases were grade 3 tumors and showed follicular and diffuse growth patterns.
CONCLUSIONS
These results indicate that Smad1 is a candidate as a germinal center marker. Furthermore, they suggest that the Smad signaling pathway might be involved in follicular lymphoma.

Keyword

Smad1; Bcl6; Lymphoma; Follicular

MeSH Terms

Diagnosis
Germinal Center
Humans
Immunohistochemistry
Lymphoid Tissue
Lymphoma
Lymphoma, Follicular*
Sensitivity and Specificity
Smad Proteins
Smad Proteins
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