J Pathol Transl Med.  2015 Mar;49(2):102-104. 10.4132/jptm.2015.02.02.

Role of Osteal Macrophages in Bone Metabolism

• Cho SW

• KMID: 2381363
• DOI: http://doi.org/10.4132/jptm.2015.02.02

Abstract

Macrophages have been shown to have pleiotropic functions in various pathophysiologies, especially in terms of anti-inflammatory and regenerative activity. Recently, the novel functions of bone marrow resident macrophages (called osteal macrophages) were intensively studied in bone development, remodeling and tissue repair processes. This review discusses the current evidence for a role of osteal macrophages in bone modeling, remodeling, and fracture healing processes.

Keyword

Osteal macrophage; Bone remodeling; Fracture healing

MeSH Terms

Bone Development
Bone Marrow
Bone Remodeling
Fracture Healing
Macrophages*
Metabolism*

Figure

• 

  Fig. 1. Osteal macrophages at the bone formation sites of murine bones. F4/80-positive osteal macrophages create a canopy-like structure over the bone remodeling site. Compare to the vehicle (VEH) treatment (A), administration of parathyroid hormones (PTH) enhances bone formation, resulting in cuboidal-changes of osteoblasts and increased recruitment of osteal macrophages at bone remodeling sites (B) [5].

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